Rheumatology International

, Volume 39, Issue 4, pp 595–604 | Cite as

Stress proteins in the pathogenesis of spondyloarthritis

  • José Pablo Romero-López
  • María Lilia Domínguez-López
  • Rubén Burgos-Vargas
  • Ethel García-LatorreEmail author


Spondyloarthritis is an autoinflammatory rheumatic disease in which arthritis and osteoproliferation lead the patients who suffer from it to chronic disability. This disease is associated with the expression of class I MHC molecule HLA-B27, which tends to be misfolded in the endoplasmic reticulum and, therefore, expressed in aberrant forms. This phenomena lead to endoplasmic reticulum stress, which in time, evokes a whole response to cellular injury. Under these conditions, the molecules involved in restoring cell homeostasis play a key role. Such is the case of the “heat-shock proteins”, which usually regulate protein folding, but also have important immunomodulatory functions, as well as some roles in tissue modeling. In this review, we attempt to summarize the involvement of cell stress and heat-shock proteins in the homeostatic disturbances and pathological conditions associated with this disease.


Spondyloarthritis Heat-shock proteins Cell stress HLA-B27 HSP60 



This work was supported by the “Consejo Nacional de Ciencia y Tecnología”, José Pablo Romero-López received scholarships from “Consejo Nacional de Ciencia y Tecnología”, and “Beca de Estímulo Institucional de Fomento para Investigadores” from “Instituto Politécnico Nacional”. Ethel García-Latorre, and María Lilia Domínguez-López receive grants from “Comisión de Operación y Fomento de Actividades Académicas”, “Estimulo al Desempeño de Investigadores” of Instituto Politécnico Nacional”, Ethel García-Latorre, Rubén Burgos-Vargas and María Lilia Domínguez López receive a grant from “Sistema Nacional de Investigadores”. We thank Julia Moreno Manjón for her critical review and help with figures. The figures were done using icons taken from

Author contributions

All the author contributed equally to the review process. JPRL and MLDL designed the figures. EGL and RBV worked in the organization, scheming and final structure of the manuscript.

Compliance with ethical standards

Conflict of interest

All the authors declare not to have any conflict of interests.


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Authors and Affiliations

  1. 1.Laboratorio de Inmunoquímica I, Departmento de Inmunología, Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico
  2. 2.Departamento de ReumatologíaHospital General de México “Dr. Eduardo Liceaga”Ciudad de MéxicoMéxico

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