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Soluble TNF receptors are produced at sites of inflammation and are inversely associated with self-reported symptoms (WOMAC) in knee osteoarthritis

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Abstract

The aim of the study was to analyze the concentrations of sTNFR1 and sTNFR2 in both plasma and synovial fluid of patients with primary knee osteoarthritis (OA) and to determine their relationship to self-reported pain, stiffness and physical function. Twenty-seven patients with knee OA and 19 healthy subjects were enrolled in the study. The Western Ontario and McMaster University Osteoarthritis Index questionnaire was used to evaluate self-reported physical function, pain and stiffness. The sTNFR1 and sTNFR2 levels in the plasma and synovial fluid were measured by enzyme-linked immunosorbent assay. The sTNFR1 levels in synovial fluid of OA patients (2,587 ± 66.12 pg/mL) were 2.5-fold higher than in corresponding blood samples and were 1.5-fold higher than in the plasma of healthy controls. The plasma sTNFR2 levels in the patients with knee OA were lower than in healthy controls (2,249 ± 126.3 vs. 2,700 ± 126.3 pg/mL, p < 0.05), and sTNFR2 levels in synovial fluid of knee OA patients (2,021 ± 107.0 pg/mL) were lower than in the plasma of healthy controls. Synovial fluid sTNFR1 levels were negatively correlated with pain and physical function self-reported (r s − 0.6785, p < 0.0001 and r s − 0.4194, p = 0.03, respectively). Synovial fluid sTNFR2 levels were negatively correlated with pain and joint stiffness (r s − 0.5433, p = 0.01 and r s − 0.4249, p = 0.02, respectively). The findings of this study demonstrated the presence of soluble receptors for TNF-alpha, particularly sTNFR1, in the synovial fluid of patients with primary knee OA and the relationship of these receptors with clinical parameters.

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Acknowledgments

CAPES, CNPq, FAPEMIG, Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas (PMPGCF) – Sociedade Brasileira de Fisiologia (SBFis), and Hospital Nossa Senhora da Saúde.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Integrated Center for Graduate Studies and Research Health (CIPq-Health), Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Minas Gerais, Brazil

    Adriano Prado Simão, Tássio Málber de Oliveira Almeida, Vanessa Amaral Mendonça, Wellington Fabiano Gomes & Ana Cristina Rodrigues Lacerda

  2. Hospital Nossa Senhora da Saúde, Diamantina, Minas gerais, Brazil

    Sérgio Antunes Santos

  3. Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Cândido Celso Coimbra

  4. Nursing School, Physiotherapy Course, Federal University of Alfenas (UNIFAL), Av. Jovino Fernandes Sales, 2600, Alfenas, Minas Gerais, 37130‑000, Brazil

    Adriano Prado Simão

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  1. Adriano Prado Simão
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  2. Tássio Málber de Oliveira Almeida
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  3. Vanessa Amaral Mendonça
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  4. Sérgio Antunes Santos
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  5. Wellington Fabiano Gomes
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  6. Cândido Celso Coimbra
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  7. Ana Cristina Rodrigues Lacerda
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Correspondence to Adriano Prado Simão.

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Simão, A.P., Almeida, T.M.O., Mendonça, V.A. et al. Soluble TNF receptors are produced at sites of inflammation and are inversely associated with self-reported symptoms (WOMAC) in knee osteoarthritis. Rheumatol Int 34, 1759–1763 (2014). https://doi.org/10.1007/s00296-014-3016-0

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  • DOI: https://doi.org/10.1007/s00296-014-3016-0

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