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Current Genetics

, Volume 65, Issue 5, pp 1161–1163 | Cite as

Regulation of the protein entry gate assembly by mitochondrial porin

  • Haruka Sakaue
  • Toshiya EndoEmail author
Mini-Review

Abstract

Mitochondrial biogenesis and functions rely on transport of their resident proteins as well as small molecules/ions across their membranes. The TOM complex functions as a protein entry gate for most mitochondrial proteins and mitochondrial porin facilitates transport of small-molecule metabolites and ions. We recently found a novel role of porin in regulation of the TOM complex assembly, the dynamic exchange between the dimer and trimer, and different substrate specificities of the dimer and trimer. Using distinct assembly forms customized for different client proteins, the TOM complex can handle ~ 1000 different mitochondrial protein for their import into mitochondria.

Keywords

Mitochondria TOM complex Porin Translocator Protein import Assembly 

Notes

Acknowledgements

This work was supported by JSPS KAKENHI to T.E. (15H05705 and 2222703) and a JST CREST grant to T.E. (JPMJCR12M1).

References

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Faculty of Life SciencesKyoto Sangyo UniversityKyotoJapan
  2. 2.Institute for Protein DynamicsKyoto Sangyo UniversityKyotoJapan

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