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Current Genetics

, Volume 65, Issue 5, pp 1127–1134 | Cite as

Not quite the SSAme: unique roles for the yeast cytosolic Hsp70s

  • Sarah K. Lotz
  • Laura E. Knighton
  • Nitika
  • Gary W. Jones
  • Andrew W. TrumanEmail author
Mini-Review

Abstract

The Heat Shock Protein 70s (Hsp70s) are an essential family of proteins involved in folding of new proteins and triaging of damaged proteins for proteasomal-mediated degradation. They are highly conserved in all organisms, with each organism possessing multiple highly similar Hsp70 variants (isoforms). These isoforms have been previously thought to be identical in function differing only in their spatio-temporal expression pattern. The model organism Saccharomyces cerevisiae (baker’s yeast) expresses four Hsp70 isoforms Ssa1, 2, 3 and 4. Here, we review recent findings that suggest that despite their similarity, Ssa isoforms may have unique cellular functions.

Keywords

Chaperone Hsp70 Ssa Isoform Evolution 

Notes

Acknowledgements

This work was supported by NCI R15CA208773 (AWT).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Biological SciencesThe University of North Carolina At CharlotteCharlotteUSA
  2. 2.Centre for Biomedical Science Research, School of Clinical and Applied SciencesLeeds Beckett UniversityLeedsUK

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