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Current Genetics

, Volume 65, Issue 2, pp 329–338 | Cite as

Genetic mechanisms of arsenic detoxification and metabolism in bacteria

  • Ge Yan
  • Xingxiang Chen
  • Shiming Du
  • Zixin Deng
  • Lianrong Wang
  • Shi ChenEmail author
Review
  • 268 Downloads

Abstract

Arsenic, distributed pervasively in the natural environment, is an extremely toxic substance which can severely impair the normal functions of living cells. Research on the genetic mechanisms of arsenic metabolism is of great importance for remediating arsenic-contaminated environments. Many organisms, including bacteria, have developed various strategies to tolerate arsenic, by either detoxifying this harmful element or utilizing it for energy generation. This review summarizes arsenic detoxification as well as arsenic respiratory metabolic pathways in bacteria and discusses novel arsenic resistance pathways in various bacterial strains. This knowledge provides insights into the mechanisms of arsenic biotransformation in bacteria. Multiple detoxification strategies among bacteria imply possible functional relationships among different arsenic detoxification/metabolism pathways. In addition, this review sheds light on the bioremediation of arsenic-contaminated environments and prevention of antibiotic resistance.

Keywords

Arsenic resistance Arsenic detoxification Arsenic metabolism Arsenic biotransformation Bacteria 

Notes

Acknowledgements

This work was supported by Grants from the National Science Foundation of China (31720103906, 31520103902, 31670072, 31670086, and 31170070).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

This work does not contain any research with human participants and/or animals.

Informed consent

Informed consent was obtained from all the authors included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Ge Yan
    • 1
    • 2
  • Xingxiang Chen
    • 1
  • Shiming Du
    • 2
  • Zixin Deng
    • 1
  • Lianrong Wang
    • 1
  • Shi Chen
    • 1
    • 2
    Email author
  1. 1.Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Zhongnan HospitalWuhan UniversityWuhanChina
  2. 2.Taihe HospitalHubei University of MedicineShiyanChina

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