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Fehlbildungen des Ösophagus

Diagnose und Therapie

Malformations of the esophagus

Diagnosis and therapy

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Zusammenfassung

Ösophageale Fehlbildungen sind selten. Sie kommen sowohl sporadisch als auch im Rahmen von Syndromen vor. Ihre Varianten und Klassifikationen sind vielfältig. Mit den zur Verfügung stehenden modernen Operationsmethoden lassen sich die meisten mit guten Ergebnissen sanieren. Häufig sind ösophageale Fehlbildungen allerdings mit weiteren Malformationen kombiniert, welche die Prognose limitieren. Die Separation von Trachea und Ösophagus nach der Gastrulation ist noch nicht vollständig erforscht. Die bisherigen Ergebnisse weisen darauf hin, dass die lokalisierte Expression verschiedener Homeodomain-Transkriptionsfaktoren essenziell für die regelrechte Entwicklung von Trachea und Ösophagus ist.

Abstract

Esophageal malformations are rare and can occur sporadically or as a component of various syndromes. The variations and classifications are manifold. With the available modern operation techniques most malformations can be resolved with good results. However, esophageal malformations are often combined with further malformations which limit the prognosis. The separation of the trachea and esophagus after gastrulation is not yet completely researched. The results so far indicate that the localzed expression of various homeodomain transcription factors is essential for normal development of the trachea and esophagus.

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Authors and Affiliations

  1. Institut für Pathologie, Klinikum Bayreuth, Preuschwitzerstr. 101, 95445, Bayreuth, Deutschland

    C. Falkeis & L. Veits

  2. Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland

    T. Hager & J. Wohlschläger

  3. Kinderradiologie, Univ.- Klinik für Kinder und Jugendheilkunde, Medizinische Universität Innsbruck, Innsbruck, Österreich

    K. Freund-Unsinn

  4. Abteilung für Kinder- und Jugendchirurgie, Department für Operative Medizin, Medizinische Universität Innsbruck, Innsbruck, Österreich

    J. Hager

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  1. C. Falkeis
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  2. T. Hager
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  4. J. Wohlschläger
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Correspondence to C. Falkeis.

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C. Falkeis/T. Hager: gleichwertige Autorenschaft/ C. Falkeis and T. Hager contributed equally.

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Falkeis, C., Hager, T., Freund-Unsinn, K. et al. Fehlbildungen des Ösophagus. Pathologe 34, 94–104 (2013). https://doi.org/10.1007/s00292-012-1733-2

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