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Polymer Bulletin

, Volume 76, Issue 5, pp 2537–2558 | Cite as

Development of extended release loxoprofen sodium multiparticulates using different hydrophobic polymers

  • Muhammad Farooq
  • Muhammad Harris ShoaibEmail author
  • Rabia Ismail Yousuf
  • Faaiza Qazi
  • Muhammad Hanif
Original Paper
  • 62 Downloads

Abstract

The objective of this study was to prepare sustained-release coated pellets of loxoprofen sodium by extrusion–spheronization technique and to assess the coating application of ethyl cellulose (10 cps), Eudragit RS100 and Eudragit RL100 on loxoprofen sodium core pellets by varying concentrations of polymeric coating. Coated pellets were evaluated for flow properties, friability, drug content and in vitro drug release in 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8 and 7.4). Minimum drug release was found in an acidic medium which was sustained in a basic medium at a higher concentration of all three polymer coats of ethyl cellulose (15%), Eudragit RS100 (10%) and Eudragit RL100 (10%). Drug–excipient compatibility was determined by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and X-ray diffraction (XRD) which showed the absence of any drug–excipient interaction. Results of image analysis and scanning electron microscopy (SEM) indicated the formation of smooth surface and spherical coated pellets. Drug release from these pellets was analyzed by using different kinetic models. Formulations F2, F4 and F5 followed first order (R2 = 0.91–0.98), while formulations F3, F6, F7 and F8 exhibited Higuchi release kinetics (R2 = 0.95–0.98). Non-Fickian diffusion (anomalous release) behavior was also observed by these formulations.

Keywords

Extrusion–spheronization Eudragit RS100 Eudragit RL100 Ethyl cellulose Loxoprofen sodium Coated pellets 

Notes

Acknowledgements

Authors are thankful to Hilton Pharma Pakistan (Pvt.) Ltd. for providing active pharmaceutical ingredients.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Muhammad Farooq
    • 1
  • Muhammad Harris Shoaib
    • 1
    Email author
  • Rabia Ismail Yousuf
    • 1
  • Faaiza Qazi
    • 1
  • Muhammad Hanif
    • 2
  1. 1.Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical SciencesUniversity of KarachiKarachiPakistan
  2. 2.Department of Pharmacy, Faculty of PharmacyBahaudin Zakaria UniversityMultanPakistan

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