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Polymer Bulletin

, Volume 76, Issue 5, pp 2215–2231 | Cite as

Photo-responsive polymeric micelles bearing ammonium salts cross-linked for efficient drug delivery

  • Lili YuEmail author
  • Lin Yao
  • Li Li
  • Shaojing Liu
  • Zhengxuan Jia
  • Di Wu
Original Paper
  • 72 Downloads

Abstract

The cationic photo-responsive polymeric micelles (mPEG-b-p(DEMA-co-MMA-CL)) with light-switchable cross-linker were designed and fabricated by atom transfer radical polymerization and quaternization. These micelles were well dispersed spherical with positive charge. The efficient release of encapsulated contents can be triggered by light irradiation. No significant toxicity was observed of copolymer and its photolysis residues at concentrations up to 250 μg/mL. The antitumor activity of camptothecin (CPT) in micelles demonstrated that light triggered the release of CPT, which dramatically improves the cytotoxicity after UV irradiation.

Keywords

Photo-responsive Polymeric micelles Drug delivery Cationic 

Notes

Acknowledgements

This work was financially supported by Natural Science Basic Research Project of Shaanxi Provincial Department of Science and Technology (2018JQ8041), the Association of Young Supporting Project of Shaanxi (20170410), the Provincial Key Discipline Construction Project of Pharmacy of Xi’an Medical University (2016YXXK03), the National Natural Science Foundation of China (81302706), Natural Science Basic Research Program of Shaanxi (2017JM8124) and the Shaanxi Provincial Education Department Project (17JK0663).

Supplementary material

289_2018_2488_MOESM1_ESM.doc (339 kb)
Supplementary material 1 (DOC 339 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Lili Yu
    • 1
    • 2
    Email author
  • Lin Yao
    • 1
    • 2
  • Li Li
    • 1
    • 2
  • Shaojing Liu
    • 1
    • 2
  • Zhengxuan Jia
    • 1
    • 2
  • Di Wu
    • 1
    • 3
  1. 1.Department of PharmacyXi’an Medical UniversityXi’anPeople’s Republic of China
  2. 2.Institute of MedicineXi’an Medical UniversityXi’anPeople’s Republic of China
  3. 3.College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’anPeople’s Republic of China

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