Polymer Bulletin

, Volume 76, Issue 5, pp 2621–2653 | Cite as

Elaboration of hydroxyapatite nanoparticles and chitosan/hydroxyapatite composites: a present status

  • Djalila BoudemaghEmail author
  • Pierre Venturini
  • Solenne Fleutot
  • Franck Cleymand


Novel formulations of nano-hydroxyapatite (nano-HAp) and nano-HAp/chitosan composites have attracted much attention in these last years. The use of natural chitosan is found to be potential for fabrication of modified nano-HAp with many biomedical applications such as orthopedic, osteoconductive, dental and drug delivery applications. This review summarizes the different techniques employed for the elaboration of HAp nanoparticles and the effect of the incorporation of HAp with chitosan on the fabrication of nano-HAp composite and on their physical properties. We discuss the effects of the reaction conditions such as reaction time, temperature, pH, solvent nature, surfactants, and concentration of reactants on crystallinity, particle size, morphology and properties of nano-HAp composite. The nano-HAp progress and the present status of HAp (either experimental or theoretical results) have been reviewed.


HAp nanoparticles Chitosan/HAp nanoparticles Preparation methodology 


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Djalila Boudemagh
    • 1
    • 2
    Email author
  • Pierre Venturini
    • 3
  • Solenne Fleutot
    • 3
  • Franck Cleymand
    • 3
  1. 1.Unité de Recherche Sciences des Matériaux et ApplicationsUniversité Constantine 1ConstantineAlgeria
  2. 2.Department of Processes EngineeringUniversity Ferhat Abbas Setif 1SetifAlgeria
  3. 3.Institut Jean Lamour (UMR CNRS 7198)Université de LorraineNancy CedexFrance

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