Synthesis of alginate/nanocellulose bionanocomposite for in vitro delivery of ampicillin
- 171 Downloads
In this study, ampicillin drug loaded with alginate and nanocellulose film was prepared by solution casting method. Nanocellulose and ampicillin incorporated into alginate to improve both mechanical and swelling properties. Interaction of ampicillin with alginate and nanocellulose was proved by ATR-FTIR spectra. The formulated ampicillin loaded Alg/NC film gave acceptable physicochemical properties compared with Alg-amp film and was able to deliver the drug in a prolonged release pattern. In vitro drug release showed that alginate could provide an immediate release of ampicillin with further enhanced nanocellulose, and followed by a sustained release over 500 min of the remaining drug. The present study exhibited a simple and useful approach to systematically design for providing drug release profiles.
KeywordsAlginate Nanocellulose Ampicillin Drug release Swelling property
The authors are grateful to Auxilium College Management for providing necessary facilities for the experimental work.
- 1.Andronescu E, Brown JM, Oktar FN (2016) Nanomaterials for medical applications: benefits and risks. J Nanomater 10:1155Google Scholar
- 2.Markstedt K, Mantas A, Tournier I (2015) 3D bioprinting human chondrocytes with nanocellulose-alginate bioink for cartilage tissue engineering applications. Biomacromol 14:486Google Scholar
- 4.Plackett DV, Letchford K (2014) A review of nanocellulose as a novel vehicle for drug delivery. NPPRJ 1:29Google Scholar
- 5.Venkatesan J, Bhatnagar I, Manivasagan P (2014) Alginate composites for bone tissue engineering: a review. Int J Biol Macromol 7(157):8Google Scholar
- 7.Jeon O, Bouhadir KH (2009) Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties. Biomaterials 1:34Google Scholar
- 8.Kaklamania G, Chenelerd D (2014) Mechanical properties of alginate hydrogels manufactured using external gelation. J Mech Behav Biomed Mater 4:13Google Scholar
- 9.Borges O, Cordeiro-da-Silva A (2006) Uptake studies in rat Peyer’s patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination. J Control Release 6:11Google Scholar
- 10.Hwang Ma-Ro, Kim JO (2010) Gentamicin-Loaded wound dressing with polyvinyl alcohol/dextran hydrogel: gel characterization and in vivo healing evaluation. Pharm Sci Tech 10:1028Google Scholar
- 11.Chaa R, Heb Z, Ni Y (2012) Preparation and characterization of thermal/pH-sensitive hydrogel from carboxylated nanocrystalline cellulose. Carbohydr Polym 1:16Google Scholar
- 12.Lin N, Bruzzese C, Dufresne A (2012) TEMPO-oxidized nanocellulose participating as crosslinking aid for alginate-based sponges. ACS Appl Mater Interfaces 10:4959Google Scholar
- 14.Tang S, Zhao Z, Chen G (2015) Fabrication of ampicillin/starch/polymer composite nanofibers with controlled drug release properties by electrospinning. J Sol Gel Sci Technol 15:3887Google Scholar