Polymer Bulletin

, Volume 75, Issue 9, pp 3971–3986 | Cite as

Preparation and characterization of chitosan–poly(vinyl alcohol)–neomycin sulfate films

  • Irina Paula Merlusca
  • Doina Simona Matiut
  • Gabriela Lisa
  • Mihaela SilionEmail author
  • Luiza Gradinaru
  • Stefan Oprea
  • Ionel Marcel Popa
Original Paper


The aim of our study was obtaining chitosan–poly(vinyl alcohol)–neomycin sulfate films (Cs–PVA–Ne) by using solvent casting technique and the characterization of the products. The films were analyzed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, thermogravimetry (TG and DTG), differential scanning calorimetry (DSC), contact angle (CA) measurements, mechanical, and antibacterial activity tests. FTIR and DSC analysis demonstrated that interaction between Cs, PVA, and Ne took place. Static water CA measurements showed an improvement in the hydrophilicity of the Cs–PVA–Ne films. Also, the drug-loaded films proved to have fairly good mechanical strength and significant effects against Staphylococcus aureus and Escherichia coli. The unloaded films show minimum bacterial inhibition (~ 10.00 mm) compared to drug-loaded films (~ 30.00 mm). The bacterial inhibition was higher in all the cases of S. aureus than E. coli. Furthermore, PVA was found to improve the films properties. Due to their physical–chemical and mechanical features and the excellent antibacterial properties, the obtained Cs–PVA–Ne films are suitable for their use as wound-dressing materials.



Silion M. is grateful for the financial support from the H2020 WIDESPREAD 2-2014: ERA Chairs Project no. 667387: SupraChemLab–Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems, ERA Chair initiative, and a grant of the Romanian National Authority for Scientific Research and Innovation, CNCS/CCCDI—UEFISCDI, project number PN-III-P3-3.6-H2020- 2016-0011, within PNCDI III.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Irina Paula Merlusca
    • 1
  • Doina Simona Matiut
    • 2
  • Gabriela Lisa
    • 1
  • Mihaela Silion
    • 3
    Email author
  • Luiza Gradinaru
    • 3
  • Stefan Oprea
    • 3
  • Ionel Marcel Popa
    • 1
    • 4
  1. 1.Faculty of Chemical Engineering and Environmental Protection“Gheorghe Asachi” Technical University of IasiIasiRomania
  2. 2.DSP-Public Health Diagnostic LaboratoryIasiRomania
  3. 3.“Petru Poni” Institute of Macromolecular ChemistryIasiRomania
  4. 4.Academy of Romanian ScientistsBucharestRomania

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