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Seminars in Immunopathology

, Volume 41, Issue 5, pp 573–582 | Cite as

Osteoclastic microRNAs and their translational potential in skeletal diseases

  • Kazuki Inoue
  • Shinichi Nakano
  • Baohong ZhaoEmail author
Review

Abstract

Skeleton undergoes constant remodeling process to maintain healthy bone mass. However, in pathological conditions, bone remodeling is deregulated, resulting in unbalanced bone resorption and formation. Abnormal osteoclast formation and activation play a key role in osteolysis, such as in rheumatoid arthritis and osteoporosis. As potential therapeutic targets or biomarkers, miRNAs have gained rapidly growing research and clinical attention. miRNA-based therapeutics is recently entering a new era for disease treatment. Such progress is emerging in treatment of skeletal diseases. In this review, we discuss miRNA biogenesis, advances in the strategies for miRNA target identification, important miRNAs involved in osteoclastogenesis and disease models, their regulated mechanisms, and translational potential and challenges in bone homeostasis and related diseases.

Keywords

Osteoclast microRNA Rheumatoid arthritis 

Notes

Acknowledgments

We thank Courtney Ng for the critical review of this manuscript.

Funding information

This work was supported by grants from the National Institutes of Health (NIH R01 AR068970 and R01 AR071463 to B.Z.).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interests.

Disclaimer

The content of this manuscript is solely the responsibilities of the authors and does not necessarily represent the official views of the NIH.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Kazuki Inoue
    • 1
    • 2
  • Shinichi Nakano
    • 1
  • Baohong Zhao
    • 1
    • 2
    • 3
    Email author
  1. 1.Arthritis and Tissue Degeneration Program and The David Z. Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkUSA
  2. 2.Department of MedicineWeill Cornell Medical CollegeNew YorkUSA
  3. 3.Graduate Program in Cell & Developmental BiologyWeill Cornell Graduate School of Medical Sciences,New YorkUSA

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