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Seminars in Immunopathology

, Volume 41, Issue 1, pp 49–58 | Cite as

Principles of adoptive T cell therapy in cancer

  • Özcan MetEmail author
  • Kasper Mølgaard Jensen
  • Christopher Aled Chamberlain
  • Marco Donia
  • Inge Marie Svane
Review

Abstract

Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers. Many ACT-based therapies have recently entered late-phase clinical testing, with several T cell therapies already achieving regulatory approval for the treatment of patients with B cell malignancies. In this review, we briefly outline the principles of adoptively transferred T cells for the treatment of cancer.

Keywords

Cancer immunotherapy Adoptive cell therapy Tumor-infiltrating lymphocytes Chimeric antigen receptor T cells 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Center for Cancer Immune Therapy, Department of HematologyCopenhagen University HospitalHerlevDenmark
  2. 2.Department of OncologyCopenhagen University HospitalHerlevDenmark
  3. 3.Department of Immunology and Microbiology, Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark

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