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Cancer Chemotherapy and Pharmacology

, Volume 84, Issue 1, pp 127–137 | Cite as

Clinical characteristics, treatment patterns and outcomes of patients older than 80 years diagnosed with DLBCL in China over a 10-year period

  • Zhan Shi
  • Xi TangEmail author
  • Qianwen Shen
  • Jiayan Chen
  • Fei Liu
  • Xi Chen
  • Jingwen Wang
  • Jie Zhuang
Original Article

Abstract

Purpose

The treatment strategy for elderly patients older than 80 years with DLBCL has not been defined yet because of poor treatment tolerability and lack of data. The aim of this trial was to retrospectively investigate clinical characteristics, treatment patterns and outcomes of patients older than 80 years diagnosed with DLBCL in China over a 10-year period.

Methods

This trial comprised 57 patients, aged ≥ 80 years, who were initial diagnosed as diffuse large B-cell lymphoma from 2007 to 2017. They received at least four cycles of reduced-dose R-CHOP21 (Rituximab 375 mg/m2 day 0, Cyclophosphamide 400 mg/m2 day1, Epirubicin 35 mg/m2 day 1, Vincristine 1 mg day 1, and Prednisone 50 mg/m2 days 1–5). An observational population-based, cohort study was performed.

Results

The median age was 82.5 years (range 80–90 years ) and the overall response rate was 73.7%. With a median 36.4-month follow-up, 2-year overall survival (OS) and 2-year progression-free survival were 74.3% and 70.9%, respectively. Using rigorous multivariate analysis, we concluded that NCCN-IPI ≥ 5 was the only predictive poor prognostic factor.

Conclusions

High response rate was concluded on very elderly DLBCL patients (≥ 80 years old) with reduced-dose R-CHOP. However, the very elderly patients with NCCN-IPI score ≥ 5 would lead to poor outcome.

Keywords

Diffuse large B-cell lymphoma Very elderly Aged R-CHOP 

Notes

Acknowledgements

We want to express great thanks for guidance of the editorial assistance from Prof. Bao zhijun, the director of the department of science and education of Shanghai Hua’Dong Hospital, PRC.

Funding

Shanghai Key Laboratory of Clinical Geriatric Medicine (No. 13DZ2260700). Research Center on Aging and Medicine, Fudan University and Shanghai Key Developing Disciplines Program (No. 2015ZB0501).

Compliance with ethical standards

Conflicts of interest

There is no conflict of interest by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medical OncologyHua’Dong Hospital Affiliated to Fudan UniversityShanghaiChina
  2. 2.Department of Radiation OncologyHua’Dong Hospital Affiliated to Fudan UniversityShanghaiChina

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