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Platinum-free interval affects efficacy of following treatment for platinum-refractory or -resistant ovarian cancer

  • Mayumi Kobayashi-Kato
  • Mayu YunokawaEmail author
  • Seiko Bun
  • Naoyuki Miyasaka
  • Tomoyasu Kato
  • Kenji Tamura
Original Article
  • 37 Downloads

Abstract

Background/objective

Platinum-refractory or -resistant ovarian cancer (PRROC) is associated with poor prognosis and low response to further chemotherapy. We investigated predictors of effectiveness of following treatments for PRROC.

Patients and methods

We included 380 patients diagnosed with stage I–IV ovarian, fallopian tube, or primary peritoneal cancer, who were treated at the National Cancer Center Hospital in Japan from January 2007 to December 2014 and recurred after initial treatment, who had a platinum-refractory or -resistant relapses and received chemotherapy, in this single-center, retrospective study. We investigated factors related to response to following treatment, and to progression-free survival (PFS).

Results

Among 183 patients (48%) who suffered recurrences, 62 (34%) developed PRROC after chemotherapy. In multivariate analysis, platinum-free interval (PFI) < 3 months was independently associated with progressive disease (odds ratio [OR] 6.043, 95% confidence interval [CI] 1.485–24.595, P = 0.012). Median PFS was 139 days (95% CI 19.4–258) among patients with PFI > 3 months, but was 57 days (95% CI 34.7–79.2) among those with PFI < 3 months. In multivariate analysis, two factors, performance status (PS) 1–2 (HR 1.915, 95% CI 1.074–3.415, P = 0.028) and PFI < 3 months (HR 1.943, 95% CI 1.109–3.403, P = 0.02), were independently associated with worse PFS.

Conclusions

PS 1–2 and PFI < 3 months were significant predictors of poor response to following treatment for PRROC. Risks and benefits of treatment should be frankly discussed with patients who have these characteristics.

Keywords

Platinum-refractory ovarian cancer Platinum-resistant ovarian cancer Predictive marker Prognostic marker Chemotherapy Platinum free interval 

Notes

Acknowledgement

We thank Marla Brunker, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of GynecologyNational Cancer Center HospitalTokyoJapan
  2. 2.Breast and Medical OncologyNational Cancer Center HospitalTokyoJapan
  3. 3.Department of Medical Oncology/Gynecologic OncologyCancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan
  4. 4.Department of PharmacyNational Cancer Center HospitalTokyoJapan
  5. 5.Department of Perinatal and Women’S MedicineTokyo Medical and Dental UniversityTokyoJapan

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