Cancer Chemotherapy and Pharmacology

, Volume 83, Issue 3, pp 425–430 | Cite as

Severe hypersensitivity reactions to platinum compounds post-pressurized intraperitoneal aerosol chemotherapy (PIPAC): first literature report

  • Matthieu Siebert
  • Mohammad AlyamiEmail author
  • Frederic Mercier
  • Colin Gallice
  • Laurent Villeneuve
  • Frédéric Bérard
  • Olivier Glehen
  • Naoual Bakrin
  • Vahan Kepenekian
Original Article



Pressurized intraperitoneal aerosol chemotherapy (PIPAC) shows encouraging results for patients with unresectable peritoneal metastasis. Several reports demonstrated the safety of the procedure combined with systemic chemotherapy, with a low rate of complication. The aim of this study is to report severe hypersensitivity reactions to platinum compounds (SHRPC) during PIPAC procedures.


All patients who underwent PIPAC for non-resectable PC in Lyon Sud University hospital were included in a prospective institutional database. All patients who presented a SHRPC after PIPAC were included in our analysis.


One hundred and thirty-two patients underwent 383 PIPAC procedures between December 2015 and December 2017. oxaliplatin’s and cisplatin–doxorubicin’s protocols were used in 71 and 312 PIPAC, respectively. Four patients (3%) developed SHRPC; two patients (2.8%) after oxaliplatin and two patients (0.6%) after cisplatin–doxorubicin protocols. SHRPC occurred during the 6th PIPAC with cisplatin–doxorubicin protocol and during 2nd and 3rd PIPAC of the oxaliplatin protocol. Three events appeared within 15 min and one event occurred 50 min following nebulization. All the SHRPC have been managed successfully without any complication.


This is the first report of SHRPC after PIPAC. The physician must constantly keep this rare but life-threatening complication in mind, especially after repeated PIPAC administration or previous platinum-based systemic chemotherapy.


Peritoneal metastasis Cisplatin Doxorubicin Oxaliplatin HIPEC Allergy SHRPC 



This study was not funded.

Compliance with ethical standards

Conflict of interest

Matthieu Siebert, Mohammad Alyami, Frederic Mercier, Colin Gallice, Laurent Villeneuve, Frédéric Bérard, Olivier Glehen, Naoual Bakrin, and Vahan Kepenekian have no conflicts of interest or financial ties to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Matthieu Siebert
    • 1
    • 2
  • Mohammad Alyami
    • 1
    • 2
    • 3
    • 5
    Email author
  • Frederic Mercier
    • 1
    • 2
  • Colin Gallice
    • 1
    • 2
  • Laurent Villeneuve
    • 1
    • 2
  • Frédéric Bérard
    • 4
  • Olivier Glehen
    • 1
    • 2
  • Naoual Bakrin
    • 1
    • 2
  • Vahan Kepenekian
    • 1
    • 2
  1. 1.Department of Surgical OncologyCentre Hospitalier Lyon-Sud, Hospices Civils de LyonPierre-BéniteFrance
  2. 2.EMR 3738, Lyon 1 UniversityLyonFrance
  3. 3.Department of General Surgery and Surgical OncologyKing Faisal Specialist Hospital and research centerRiyadhSaudi Arabia
  4. 4.Service d’Allergologie et Immunologie CliniqueINSERM U851Pierre-BéniteFrance
  5. 5.Département de Chirurgie Générale, Digestive et EndocrinienneCHU Lyon SudPierre-BéniteFrance

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