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Cancer Chemotherapy and Pharmacology

, Volume 83, Issue 1, pp 131–143 | Cite as

Pertuzumab, trastuzumab and taxane-based treatment for visceral organ metastatic, trastuzumab-naïve breast cancer: real-life practice outcomes

  • Ece EsinEmail author
  • B. Oksuzoglu
  • A. Bilici
  • I. Cicin
  • O. Kostek
  • M. A. Kaplan
  • S. Aksoy
  • B. Y. Aktas
  • O. Ozdemir
  • A. Alacacioglu
  • D. Cabuk
  • A. T. Sumbul
  • A. Sakin
  • S. Paydas
  • E. Yetisir
  • O. Er
  • T. Korkmaz
  • N. Yildirim
  • T. Sakalar
  • H. Demir
  • M. Artac
  • M. Karaagac
  • H. Harputluoglu
  • E. Bilen
  • E. Erdur
  • S. Degirmencioglu
  • A. Aliyev
  • T. Cil
  • P. Olgun
  • G. Basaran
  • O. Gumusay
  • A. Demir
  • E. Tanrikulu
  • P. F. Yumuk
  • Inanc Imamoglu
  • B. Oyan
  • B. Cetin
  • V. Haksoyler
  • N. Karadurmus
  • I. Erturk
  • T. Evrensel
  • H. Yilmaz
  • I. Beypinar
  • M. Kocer
  • K. N. Pilanci
  • M. Seker
  • Y. Urun
  • N. Yildirim
  • T. Eren
  • U. Demirci
  • Turkish Oncology Group
Original Article
  • 189 Downloads

Abstract

Purpose

In this study, we aimed to describe the real-life practice outcomes of pertuzumab–trastuzumab–taxane (PTT) combination in visceral organ metastatic, trastuzumab-naive breast cancer (BC) patients.

Methods

This study was conducted by Turkish Oncology Group and included 317 patients’ data from 36 centers.

Results

Median age was 51 (22–82). Median PFS was 28.5 months, while median OS was 40.3 months. Patients with brain metastases (n: 13, 4.1%) had worse PFS (16.8 m vs. 28.5 m; p = 0.002) and OS (26.7 m vs. 40.3 m; p = 0.009). Patients older than 65 years of age (n: 42, 13.2%) had significantly lower OS results (19.8 m vs. 40.3 m; p = 0.01). Two hundred sixty-eight patients (86.7%) received docetaxel while 37 patients (11.7%) received paclitaxel. PFS and OS were similar between taxane groups. In eight patients (2.5%), 5–40% ejection fraction decrement from baseline was detected without any clinical sign of heart failure.

Conclusions

Our RLP trial included only visceral metastatic, trastuzumab-naïve BC patients including cases with brain involvement who received PTT combination in the first-line treatment. Regardless of negative prognostic characteristics, our results are in parallel with pivotal trial. Further strategies for brain metastasis should be developed to improve outcomes despite encouraging results with PTT treatment. Taxane selection can be personalized and endocrine maintenance may further improve outcomes after taxanes were discontinued. To our knowledge, this is the largest scale real-life clinical practice study of pertuzumab–trastuzumab–taxane therapy to date.

Keywords

Pertuzumab Trastuzumab AntiHER2 Visceral metastasis Brain metastasis 

Notes

Acknowledgements

Turkish Oncology Group (TOG) represented by Esin E., Oksuzoglu B., Bilici A., Kostek O., Cicin I., Kaplan M. A., Aktas B. Y., S. Aksoy, Ozdemir O., Alacacioglu A., Cabuk D., Sumbul A. T., Sakin A., Yetisir E., Paydas S., Er O., Korkmaz T., Yildirim N., Sakalar T., Demir H., Karaagac M., Artac M., Harputluoglu H., Bilen E., Degirmencioglu S., Aliyev A., Olgun P., Cil T., Basaran G., Gumusay O., Demir A., Tanrikulu E., Yumuk P. F., Imamoglu I., Uluc Oyan B., Cetin B., Haksoyler V., Karadurmus N., Erturk I., Yilmaz H., Evrensel T., Beypinar, Kocer, Pilanci K. N., Seker M., Urun Y., Yildirim N., Eren T., Demirci U.

Authors’ contribution

All of the authors contribute to data collection. Concept: EE, BO, UD, GB; Design: EE, BO, UD; Supervision: BO, UD; Analysis and/or Interpretation: EE, UD, IC; Writing: EE; Critical Reviews: BO, UD, FY, AB, IC.

Funding

None declared.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethics approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the committee of University of Health Sciences, Ankara Oncology Education and Research Hospital (TUEK meeting number: 40-15.5.2018).

Human/animal rights statement

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Given the retrospective nature of the study, written informed consent was not mandatory according to local regulations.

Consent for publication

Not available.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Ece Esin
    • 1
    Email author
  • B. Oksuzoglu
    • 1
  • A. Bilici
    • 2
  • I. Cicin
    • 3
  • O. Kostek
    • 3
  • M. A. Kaplan
    • 4
  • S. Aksoy
    • 5
  • B. Y. Aktas
    • 5
  • O. Ozdemir
    • 6
  • A. Alacacioglu
    • 6
  • D. Cabuk
    • 7
  • A. T. Sumbul
    • 8
  • A. Sakin
    • 9
  • S. Paydas
    • 10
  • E. Yetisir
    • 10
  • O. Er
    • 11
  • T. Korkmaz
    • 12
  • N. Yildirim
    • 13
  • T. Sakalar
    • 14
  • H. Demir
    • 15
  • M. Artac
    • 16
  • M. Karaagac
    • 16
  • H. Harputluoglu
    • 17
  • E. Bilen
    • 17
  • E. Erdur
    • 1
  • S. Degirmencioglu
    • 18
  • A. Aliyev
    • 19
  • T. Cil
    • 20
  • P. Olgun
    • 20
  • G. Basaran
    • 11
  • O. Gumusay
    • 21
  • A. Demir
    • 22
  • E. Tanrikulu
    • 23
  • P. F. Yumuk
    • 23
  • Inanc Imamoglu
    • 24
  • B. Oyan
    • 12
  • B. Cetin
    • 25
  • V. Haksoyler
    • 26
  • N. Karadurmus
    • 27
  • I. Erturk
    • 27
  • T. Evrensel
    • 28
  • H. Yilmaz
    • 28
  • I. Beypinar
    • 29
  • M. Kocer
    • 30
  • K. N. Pilanci
    • 31
  • M. Seker
    • 32
  • Y. Urun
    • 33
  • N. Yildirim
    • 34
  • T. Eren
    • 34
  • U. Demirci
    • 1
  • Turkish Oncology Group
  1. 1.Department of Medical Oncology, Dr. A. Y. Ankara Oncology Education and Research HospitalUniversity of Health SciencesAnkaraTurkey
  2. 2.Departmant of Medical OncologyMedipol University International Health CenterIstanbulTurkey
  3. 3.Department of Medical OncologyTrakya UniversityEdirneTurkey
  4. 4.Department of Medical Oncology, Faculty of MedicineDicle UniversityDiyarbakirTurkey
  5. 5.Department of Medical Oncology, Faculty of MedicineHacettepe UniversityAnkaraTurkey
  6. 6.Department of Medical Oncology, Ataturk Education and Research Hospitalİzmir K.C. UniversityIzmirTurkey
  7. 7.Department of Medical Oncology, Faculty of MedicineKocaeli UniversityIzmitTurkey
  8. 8.Department of Medical OncologyBaskent University Adana HospitalAdanaTurkey
  9. 9.Department of Medical OncologyIstanbul Okmeydani Education and Research HospitalIstanbulTurkey
  10. 10.Department of Medical Oncology, Faculty of MedicineCukurova UniversityAdanaTurkey
  11. 11.Department of Medical Oncology, Acibadem Maslak HospitalAcibadem MAA UniversityIstanbulTurkey
  12. 12.Department of Medical Oncology, Acibadem Altunizade HospitalAcibadem MAA UniversityIstanbulTurkey
  13. 13.Department of Medical OncologyDr. Ersin Arslan Training and Research HospitalGaziantepTurkey
  14. 14.Department of Medical Oncology, Faculty of MedicineErciyes UniversityKayseriTurkey
  15. 15.Department of Medical Oncology, Kayseri Education and Research HospitalUniversity of Health SciencesKayseriTurkey
  16. 16.Department of Medical Oncology, Meram Medical FacultyNecmettin Erbakan UniversityKonyaTurkey
  17. 17.Department of Medical Oncology, Turgut Ozal Medical CenterInonu UniversityMalatyaTurkey
  18. 18.Department of Medical Oncology, Faculty of MedicinePamukkale UniversityDenizliTurkey
  19. 19.Department of Medical Oncology, Faculty of MedicineBezmialem UniversityIstanbulTurkey
  20. 20.Department of Medical Oncology, Adana City HospitalUniversity of Health SciencesAdanaTurkey
  21. 21.Department of Medical Oncology, Faculty of MedicineGaziosmanpasa UniversityTokatTurkey
  22. 22.Department of Medical Oncology, Istanbul Okmeydani Education and Research HospitalUniversity of Health SciencesIstanbulTurkey
  23. 23.Department of Medical Oncology, Faculty of MedicineMarmara UniversityIstanbulTurkey
  24. 24.Department of Medical Oncology, Ankara Diskapi Education and Research HospitalUniversity of Health SciencesAnkaraTurkey
  25. 25.Department of Medical Oncology, Faculty of MedicineRTE UniversityRizeTurkey
  26. 26.Department of Medical Oncology, Diyarbakir G.Y. Education and Research HospitalUniversity of Health SciencesDiyarbakirTurkey
  27. 27.Department of Medical Oncology, Gulhane Education and Research HospitalUniversity of Health SciencesAnkaraTurkey
  28. 28.Department of Medical Oncology, Faculty of MedicineUludag UniversityBursaTurkey
  29. 29.Department of Medical Oncology, Faculty of MedicineAfyon Kocatepe UniversityAfyonTurkey
  30. 30.Department of Medical Oncology, Faculty of MedicineIsparta S.D UniversityIspartaTurkey
  31. 31.Department of Medical Oncology, Haseki Education and Research HospitalUniversity of Health SciencesIstanbulTurkey
  32. 32.Department of Medical OncologyAnkara Bayindir HospitalAnkaraTurkey
  33. 33.Department of Medical Oncology, Faculty of MedicineAnkara UniversityAnkaraTurkey
  34. 34.Department of Medical Oncology, Numune Education and Research HospitalUniversity of Health SciencesAnkaraTurkey

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