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Efficacy and safety of micafungin in unrelated cord blood transplant recipients

  • Takeo Yasu
  • Takaaki KonumaEmail author
  • Maki Oiwa-Monna
  • Mai Mizusawa
  • Masamichi Isobe
  • Seiko Kato
  • Satoshi Takahashi
  • Arinobu Tojo
Original Article

Abstract

Micafungin (MCFG) is an echinocandin antifungal drug used for prophylaxis and treatment of fungal infections after allogeneic hematopoietic cell transplantation (HCT). However, its efficacy and safety in patients undergoing cord blood transplantation (CBT) has not been clarified. We retrospectively analyzed the efficacy and safety of MCFG in 92 adult patients undergoing CBT in our institute. Of the entire cohort, 83 patients (90%) received MCFG for empirical or preemptive therapy. Documented breakthrough fungal infection occurred in 2 patients during MCFG treatment. Among the 49 patients who received MCFG as empirical therapy for febrile neutropenia, 41 (84%) patients had resolution of fever during neutropenia. Elevation of serum levels of hepatobiliary parameters during MCFG treatment was commonly observed, but grade 3 or higher elevation was rare. We also compared the efficacy and safety of 2 different initial daily doses of MCFG (150 mg vs. 300 mg). There were no significant differences of efficacy and safety between the two groups. These data suggest that MCFG was effective and safe for adult patients undergoing CBT. The optimal daily dose of MCFG treatment is a matter of future investigation for adult patients undergoing CBT.

Keywords

Micafungin Cord blood transplantation Efficacy Adverse events Daily dose Echinocandin 

Notes

Acknowledgments

The authors thank all of the physicians and staff at out hospital in this study.

Compliance with ethical standards

This case study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Conflict of interest

The authors declare that they have no conflicts of interest.

Supplementary material

277_2019_3790_MOESM1_ESM.docx (43 kb)
ESM 1 (DOCX 43.4 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pharmacy, The Institute of Medical ScienceThe University of TokyoTokyoJapan
  2. 2.Department of Hematology/Oncology, The Institute of Medical ScienceThe University of TokyoTokyoJapan

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