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The prognostic significance of Wilms’ tumor gene 1 (WT1) expression at diagnosis in adults with Ph-negative B cell precursor acute lymphoblastic leukemia

  • Ya-Zhen Qin
  • Qian JiangEmail author
  • Lan-Ping Xu
  • Hao Jiang
  • Yu Wang
  • Xiao-Su Zhao
  • Zong-Ru Li
  • Yue-Yun Lai
  • Yan-Rong Liu
  • Xiao-Hui Zhang
  • Kai-Yan Liu
  • Xiao-Jun Huang
Original Article
  • 34 Downloads

Abstract

The prognostic significance of Wilms’ tumor gene 1 (WT1) expression at diagnosis in adults with B cell precursor acute lymphoblastic leukemia (BCP-ALL) remains poorly understood. A total of 257 adults with Ph-negative BCP-ALL who were consecutively diagnosed and received at least 1 course of induction therapy at our institute were retrospectively analyzed. The WT1 expression patterns were significantly different among the molecularly and cytogenetically defined groups (E2A-PBX1, TEL-AML1, and MLL rearrangements; high hyperdiploidy and B-other). By considering the WT1 expression pattern and the relapse status, 2 cutoff values, 1.8% and 7.2%, were arbitrarily selected to place patients into WT1-low, WT1-inter, and WT1-high groups. In the B-other patients who achieved complete remission (CR), WT1-low and WT1-high patients had similar 3-year relapse-free survival (RFS), disease-free survival (DFS), and overall survival (OS) rates, which were all significantly lower than those of WT1-inter patients. The combined WT1-low/high expression group (n = 132) had significantly lower 3-year RFS, DFS, and OS rates compared with the WT1-inter group (n = 63) of B-other patients (RFS and DFS all P < 0.0001; OS P = 0.0018 and 0.0008). WT1 low/high expression as well as treating with chemotherapy only was independent poor prognostic factors for RFS, DFS, and OS in the B-other patients who achieved CR. Therefore, the molecularly and cytogenetically defined adult Ph-negative BCP-ALL groups have characteristic WT1 expression patterns, and WT1 low/high expression at diagnosis predicts poor outcome in B-other patients.

Keywords

B cell precursor acute lymphoblastic leukemia Ph-negative WT1 transcript levels At diagnosis Prognosis 

Notes

Funding information

This work was supported by the National Natural Science Foundation of China (81870125, 81770161, and 81570130) and Scientific Research Foundation for Capital Medicine Development (2016-1-4082).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Peking University People’s Hospital.

Informed consent

For this retrospective study, formal content is not required.

Supplementary material

277_2019_3789_MOESM1_ESM.docx (531 kb)
ESM 1 (DOCX 530 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Ya-Zhen Qin
    • 1
  • Qian Jiang
    • 1
    • 2
    Email author
  • Lan-Ping Xu
    • 1
  • Hao Jiang
    • 1
  • Yu Wang
    • 1
  • Xiao-Su Zhao
    • 1
  • Zong-Ru Li
    • 1
  • Yue-Yun Lai
    • 1
  • Yan-Rong Liu
    • 1
  • Xiao-Hui Zhang
    • 1
  • Kai-Yan Liu
    • 1
  • Xiao-Jun Huang
    • 1
    • 3
  1. 1.Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic DiseaseBeijingChina
  2. 2.Collaborative Innovation Center of HematologySoochow UniversitySuzhouChina
  3. 3.Peking-Tsinghua Center for Life SciencesBeijingChina

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