How to resolve a clinical and molecular puzzle: concomitant monoclonal gammopathy of undetermined significance (MGUS) with neutrophilia and clonal hematopoiesis of indeterminate potential (CHIP)
The association between plasma cell (PC) neoplasms (PCN) and neutrophilia is a rare but well-known phenomenon [1, 2, 3]. CHIP designates asymptomatic presence of clones in the peripheral blood and/or the bone marrow carrying somatic mutations of genes, typically mutated in myeloid neoplasms, with a not exactly predictable risk of progression towards cancer, bearing analogies to MGUS and monoclonal B-lymphocytosis [4, 5]. We report on a patient with concomitant MGUS, neutrophilia, and CHIP, rising questions of the nature of neutrophilia in PCN as well as caveats of overinterpretation due to the simultaneous co-existence of MGUS and CHIP.
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The authors declare that they have no conflict of interest.
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