Annals of Hematology

, Volume 98, Issue 10, pp 2437–2438 | Cite as

Chronic lymphocytic leukemia with plasmacytic differentiation

  • Kirill A. Lyapichev
  • Habibe Kurt
  • Narittee Sukswai
  • Sergej Konoplev
  • Carlos E. Bueso-Ramos
  • Joseph D. Khoury
  • Yang O. HuhEmail author
Letter to the Editor

Dear Editor,

A 71-year-old woman was initially diagnosed with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) at age 63. The original bone marrow biopsy demonstrated 60% involvement by lymphoma with no unusual morphological presentation. Flow cytometry study showed the immunophenotype consistent with CLL/SLL with lambda light chain-restriction. CD38 and ZAP70 were negative. Additionally, FISH and molecular studies demonstrated monosomy of chromosome 12, del13q, and TP53 gene deletion. Due to persistence of the neoplasm, despite on original treatment with idelalisib plus rituximab for 5 years, the patient was placed on ibrutinib and venetoclax therapy. The post-therapy evaluation was scheduled and performed at our institution. The bone marrow biopsy showed markedly increased number of atypical lymphocytes with interstitial and nodular distribution pattern involving approximately 50% of marrow cellularity. Interestingly, in addition to lymphoma cells, occasional large...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of PathologyChulalongkorn UniversityBangkokThailand

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