Annals of Hematology

, Volume 98, Issue 10, pp 2439–2441 | Cite as

HHV-8- and EBV-positive germinotropic lymphoproliferative disorder

  • Magda Zanelli
  • Giulio Fraternali Orcioni
  • Maurizio ZizzoEmail author
  • Loredana De Marco
  • Giovanni Martino
  • Giulia Cerrone
  • Antonello Domenico Cabras
  • Stefano Ascani
Letter to the Editor

Dear Editor,

A 72-year-old HIV-negative female presented with a 7-month history of palpable, non-tender left cervical lymph node. She had no fever or other systemic symptoms. No splenomegaly or hepatomegaly was present. Peripheral blood tests were within normal limits. A total body computed tomography (CT) scan confirmed a 2-cm isolated cervical lymph node, which was surgically removed. Histologically, lymph node architecture was partially effaced. Aggregates of plasmablasts partially or totally replaced germinal centers (GC) (Figs.  1 and 2). Numerous plasma cells were present in the inter-follicular areas. Some follicles showed Castleman-like features with hyalinized, atrophic GC (Fig.  3). Plasmablasts were co-infected by human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV), being positive for HHV-8 (Fig. 1, inset left) and EBV by in situ hybridization (EBER) (Fig. 1, inset right). These cells were diffusely positive for CD38 (Fig. 2, inset), MUM1/IRF4, and immunoglobulin light...


Compliance with ethical standards

Conflict of interest

The authors declare they have no conflict of interest.

Ethical approval

Local ethics committee (Comitato Etico dell’Area Vasta Emilia Nord, Italy) ruled that no formal ethics approval was required in this particular case.

Informed consent

Written informed consent was obtained from patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Magda Zanelli
    • 1
  • Giulio Fraternali Orcioni
    • 2
  • Maurizio Zizzo
    • 3
    • 4
    Email author
  • Loredana De Marco
    • 1
  • Giovanni Martino
    • 5
  • Giulia Cerrone
    • 6
  • Antonello Domenico Cabras
    • 7
  • Stefano Ascani
    • 8
  1. 1.Pathology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio EmiliaReggio EmiliaItaly
  2. 2.Pathology Unit, Azienda Ospedaliera di CuneoCuneoItaly
  3. 3.Surgical Oncology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio EmiliaReggio EmiliaItaly
  4. 4.Department of Oncology and Advanced Technologies, Surgical, Clinical and Experimental Medicine PhD ProgramUniversity of Modena and Reggio EmiliaModenaItaly
  5. 5.Hematology Unit, CREO, Azienda Ospedaliera di PerugiaUniversity of PerugiaPerugiaItaly
  6. 6.Pathology Unit, University of CagliariCagliariItaly
  7. 7.Hematopathology Unit, Istituto Nazionale dei Tumori-IRCCSMilanItaly
  8. 8.Pathology Unit, Azienda Ospedaliera S. Maria di TerniUniversity of PerugiaPerugiaItaly

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