Clinicohematologic and cytogenetic profile in a rare case of pure erythroid leukemia
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Pure erythroid leukemia (PEL) represents a rare and clinically aggressive type of acute leukemia. It accounts for less than 1% of acute myeloid leukemia (AML) . PEL is the only type of acute erythroid leukemia, as per 2016 WHO classification, which is characterized by neoplastic proliferation of immature erythroblasts with > 80% immature erythroid precursors in the bone marrow of which ≥ 30% are proerythroblasts with no significant myeloblast component . PEL often evolves from prior myelodysplastic syndrome (MDS), commonly with morphological dysplasia, but can also develop de novo. We report here a case of PEL with complex karyotype showing multiple cytogenetic abnormalities.
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The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 5.Montalban-Bravo G, Benton CB, Wang SA, Ravandi F et al (2016) Pure erythroid leukemia is characterized by TP53mutations, a complex karyotype with chromosome 17 abnormalities, and adverse risk independent of therapy type. Blood. 128(22):2852Google Scholar