Annals of Hematology

, Volume 98, Issue 8, pp 2005–2007 | Cite as

Clinicohematologic and cytogenetic profile in a rare case of pure erythroid leukemia

  • Smeeta Gajendra
  • Anil Kumar Yadav
  • Bhuvan Chugh
  • Nitin Sood
  • Manorama BhargavaEmail author
Letter to the Editor

Dear Editor,

Pure erythroid leukemia (PEL) represents a rare and clinically aggressive type of acute leukemia. It accounts for less than 1% of acute myeloid leukemia (AML) [1]. PEL is the only type of acute erythroid leukemia, as per 2016 WHO classification, which is characterized by neoplastic proliferation of immature erythroblasts with > 80% immature erythroid precursors in the bone marrow of which ≥ 30% are proerythroblasts with no significant myeloblast component [2]. PEL often evolves from prior myelodysplastic syndrome (MDS), commonly with morphological dysplasia, but can also develop de novo. We report here a case of PEL with complex karyotype showing multiple cytogenetic abnormalities.

A 65-year-old male, transfusion dependent, presented with pancytopenia. His hemoglobin was 84 g/L; total leucocyte and platelet counts were 1.76 × 10 9/L and 16 × 10 9/L, respectively, with 2% blasts in peripheral blood smear. Bone marrow (BM) aspirate smears (Fig.  1a, b) were hypercellular,...


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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of HematopathologyMedanta – The MedicityGurgaonIndia
  2. 2.Department of Medical Oncology & HematologyMedanta – The MedicityGurgaonIndia

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