Annals of Hematology

, Volume 98, Issue 8, pp 1991–1992 | Cite as

Successful management of transcatheter aortic valve implantation by platelet transfusions in a nonagenarian patient with severe autoimmune factor V deficiency

  • Christine Mouton
  • Lionel Leroux
  • Guillaume Bonnet
  • Benjamin Seguy
  • Aurélie Lafargue
  • Gildas Baulier
  • Sabine Castet
  • Mathieu FioreEmail author
Letter to the Editor

Dear Editor,

The most common acquired inhibitors to coagulation factors, after factor VIII or von Willebrand factor, are directed against factor V (FV) [1, 2, 3]. Bleeding risk associated with FV inhibitors is highly variable with poor correlation to coagulation studies rendering this disease challenging to manage [4]. Here, we report the successful management of a transcatheter aortic valve implantation (TAVI), using platelet concentrates, in a nonagenarian patient with severe FV inhibitors.

The patient was a 93-year-old woman who was hospitalized in an emergency situation due to acute congestive heart failure. The cause of heart disease included coronary artery diseases, atrial fibrillation, and severe aortic stenosis. During her hospitalization, she developed urinary tract infection treated by ceftriaxone.

Few days later, cardiologists decided to undergo coronary angiography. However, systematic preoperative monitoring revealed very prolonged prothrombin time (PT: 225 s) and...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethic statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from the patient for being included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratoire d’hématologie, Hôpital cardiologiqueCentre Hospitalo-Universitaire de BordeauxPessacFrance
  2. 2.Service de cardiologie interventionnelle, Hôpital cardiologiqueCentre Hospitalo-Universitaire de BordeauxPessacFrance
  3. 3.Unité de de Soins Intensifs et Continus de Cardiologie, Hôpital cardiologiqueCentre Hospitalo-Universitaire de BordeauxPessacFrance
  4. 4.Unité mobile de gériatrie, Hôpital Saint-AndréCentre Hospitalo-Universitaire de BordeauxBordeauxFrance
  5. 5.Service de médecine interne et immunologie clinique, Hôpital Saint-AndréCentre Hospitalo-Universitaire de BordeauxBordeauxFrance
  6. 6.Centre de Ressources et de Compétences des Maladies Hémorragiques Constitutionnelles, Hôpital PellegrinCentre Hospitalo-Universitaire de BordeauxBordeauxFrance
  7. 7.Centre de Référence des Pathologies Plaquettaires Constitutionnelles, Hôpital cardiologiqueCentre Hospitalo-Universitaire de BordeauxPessacFrance
  8. 8.Laboratoire d’HématologieHôpital CardiologiquePessacFrance

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