Unusual transformation of primary extranodal marginal zone B cell lymphoma of the uterus into a nodal follicular lymphoma grade IIIB
- 11 Downloads
According to the WHO classification of non-Hodgkin lymphoma, extranodal marginal zone B cell lymphomas of mucosa-associated lymphatic tissue (MALT) is defined as a group of NHL (non-Hodgkin lymphoma) that account for approximately 7–8% of all B cell lymphomas . The most common location of MALT is the gastrointestinal tract. A manifestation of the uterus is a rarity and to our best knowledge, fewer than 20 case reports of marginal zone B cell lymphoma of the uterus have been reported so far in literature [2, 3].
The histological transformation into an aggressive lymphoma occurs in approximately 4% and is associated with an inferior treatment outcome . MALT lymphoma is characterized by recurrent chromosomal translocations, leading to the activation of the NF-ĸB signaling pathway.
This work was supported by a grant from the Deutsche Krebsgesellschaft (grant no 70113057 to AG and CB).
Compliance with ethical standards
Ethical standards and patient informed consent
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from the patient for being included in the study.
Conflicts of interest
The authors declare that they have no conflict of interest.
- 1.Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127(20):2375–2390. https://doi.org/10.1182/blood-2016-01-643569 CrossRefGoogle Scholar
- 2.Takimoto T, Maegawa S, Tatsumi H, Nagoshi H, Chinen Y, Shimura Y, Kobayashi T, Horiike S, Nakamura S, Kitawaki J, Kuroda J, Taniwaki M (2017) Extranodal marginal zone lymphoma of the uterine cervix with concomitant copy number gains of the MALT1 and BCL2 genes: a case report. Oncol Lett 13(5):3641–3645. https://doi.org/10.3892/ol.2017.5944 CrossRefGoogle Scholar
- 3.Magnoli F, Cimetti L, Bernasconi B, Sahnane N, Redaelli I, Riva C, Uccella S (2016) Primary extranodal marginal cell lymphoma, MALT type, of the endometrium arising in a patient with rheumatoid arthritis: report of a case. Int J Gynecol Pathol 35(4):327–332. https://doi.org/10.1097/PGP.0000000000000244 CrossRefGoogle Scholar
- 5.Conconi A, Franceschetti S, Aprile von Hohenstaufen K, Margiotta-Casaluci G, Stathis A, Moccia AA, Bertoni F, Ramponi A, Mazzucchelli L, Cavalli F, Gaidano G, Zucca E (2015) Histologic transformation in marginal zone lymphomasdagger. Ann Oncol 26(11):2329–2335. https://doi.org/10.1093/annonc/mdv368 CrossRefGoogle Scholar
- 6.Dreyling M, Thieblemont C, Gallamini A, Arcaini L, Campo E, Hermine O, Kluin-Nelemans JC, Ladetto M, Le Gouill S, Iannitto E, Pileri S, Rodriguez J, Schmitz N, Wotherspoon A, Zinzani P, Zucca E (2013) ESMO consensus conferences: guidelines on malignant lymphoma. Part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma. Ann Oncol 24(4):857–877. https://doi.org/10.1093/annonc/mds643 CrossRefGoogle Scholar
- 7.Treglia G, Zucca E, Sadeghi R, Cavalli F, Giovanella L, Ceriani L (2015) Detection rate of fluorine-18-fluorodeoxyglucose positron emission tomography in patients with marginal zone lymphoma of MALT type: a meta-analysis. Hematol Oncol 33(3):113–124. https://doi.org/10.1002/hon.2152 CrossRefGoogle Scholar