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Cytomegalovirus infection is associated with AML relapse after allo-HSCT: a meta-analysis of observational studies

  • Yu-Lin Zhang
  • Yan Zhu
  • Qing Xiao
  • Li Wang
  • Lin Liu
  • Xiao-Hua LuoEmail author
Original Article

Abstract

Cytomegalovirus (CMV) infection and primary disease relapse remain challenging problems after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We sought to assess the association between CMV infection and disease relapse after transplantation. PubMed, EMBASE, the Cochrane Library, SCI, and Chinese Biomedicine Databases were searched up to July 1, 2018, for all studies that investigate pre-transplant CMV serostatus, CMV replication, and primary disease relapse in allo-HSCT patients with hematologic malignancies. Meta-analysis of 24 eligible cohort studies showed a significantly lower relapse risk after allo-HSCT in patients with CMV replication in acute myeloid leukemia (AML) (HR = 0.64, 95% CI, 0.50–0.83; P < 0.001) subgroup. However, CMV replication was associated with increased non-relapse mortality (NRM) in AML patients (HR = 1.64, 95% CI, 1.46–1.85; P < 0.001), but not associated with overall survival (OS) or graft-versus-host disease for AML patients (P > 0.05). There was no association between pre-transplant CMV serostatus and disease relapse, although D−/R− was associated with better OS in acute leukemia patients (HR = 0.89, 95% CI, 0.83–0.96; P = 0.003). In AML patients, CMV replication may be a protective predictor against disease relapse, although the potential benefit of CMV replication is offset by increased NRM.

Keywords

Cytomegalovirus infection Relapse Acute myeloid leukemia Allogeneic hematopoietic stem cell transplantation Meta-analysis 

Notes

Funding

This work was supported by the National Natural Science Foundation of China (grant 81100388, grant 81470344).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the local institutional review board.

Supplementary material

277_2018_3585_MOESM1_ESM.docx (30 kb)
ESM 1 (DOCX 30.2 kb)
277_2018_3585_MOESM2_ESM.doc (98 kb)
ESM 2 (DOC 98.0 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Yu-Lin Zhang
    • 1
  • Yan Zhu
    • 2
  • Qing Xiao
    • 1
  • Li Wang
    • 1
  • Lin Liu
    • 1
  • Xiao-Hua Luo
    • 1
    Email author
  1. 1.Department of HematologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina
  2. 2.Department of Hematology, Southwest HospitalThird Military Medical University (Army Medical University)ChongqingChina

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