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Annals of Hematology

, Volume 98, Issue 3, pp 605–614 | Cite as

Retrospective evaluation of bone marrow cell morphology in a cohort of patients with isolated idic(20q-) karyotypic abnormalities

  • Dandan Liu
  • Jinlan Pan
  • Chunxiao Wu
  • Jianying Liang
  • Jingjing Wang
  • Suning Chen
  • Zixing ChenEmail author
Original Article
  • 49 Downloads

Abstract

Isochromosome 20q- (i(20q-)), as a rare reproducible chromosomal anomaly formed on the basis of 20q-, has not been commonly reported. Due to the rarity of this karyotypic anomaly, the bone marrow morphological characteristics of the patients with i(20q-) have not been clarified until now. In this study, the bone marrow cell morphology from MDS patients with isolated i(20q-), isolated 20q-, and normal karyotype was retrospectively compared and statistically analyzed. The results indicated that the isolated i(20q-) was mostly detected in MDS-MLD patients. The frequency and proportion dysplasia of cytoplasmic vacuolization in erythoid cells and small or unusually large size in myeloid cells of isolated i(20q-) MDS patients were significantly higher than those of normal karyotype MDS patients respectively (P < 0.05); the frequency and proportion dysplasia of decreased granules/agranularity in myeloid cells of isolated i(20q-) MDS patients were higher than those of isolated 20q- MDS patients (P < 0.05). The incidence of some specific morphological manifestations, such as deeply lobulated and hyperlobulated megakaryocytes and hypogranular and vacuolized eosinophils, may be an important morphological implication for the anomaly of isolated i(20q-). These morphological features of dysplasia may be helpful in distinguishing MDS with isolated i(20q-) from those with isolated 20q- and normal karyotype.

Keywords

Isolated i(20q-) Isolated 20q- Myelodysplastic syndrome Morphological dysplasia 

Notes

Author contributions

Dandan Liu, Jinlan Pan, and Chunxiao Wu contributed equally to this paper.

Funding information

This work was supported in part by the Youth National Natural Science Foundation of China (grant number 81100332) and the Natural Science Foundation of Jiangsu Province (grant number BK20151231).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Dandan Liu
    • 1
  • Jinlan Pan
    • 1
  • Chunxiao Wu
    • 1
  • Jianying Liang
    • 1
  • Jingjing Wang
    • 1
  • Suning Chen
    • 1
  • Zixing Chen
    • 1
    Email author
  1. 1.The First Affiliated Hospital of Soochow UniversityJiangsu Institute of HematologySuzhouPeople’s Republic of China

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