Annals of Hematology

, Volume 98, Issue 4, pp 1045–1046 | Cite as

Anti-glomerular basement membrane disease due to monoclonal IgG Lambda antibodies: a very rare case of monoclonal gammopathy of renal significance

  • C. Peña
  • R. Valjalo
  • X. Rocca
  • M. Roa
  • A. Morales
  • G. P. Méndez
Letter to the Editor


Antiglomerular basement membrane antibody Plasma cells Paraproteinemias Thalidomide Plasmapheresis 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


  1. 1.
    Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA (2012) International kidney and monoclonal gammopathy research group. Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood 120:4292–4295CrossRefPubMedGoogle Scholar
  2. 2.
    Coley SM, Shirazian S, Radhakrishnan J, D’Agati VD (2015) Monoclonal IgG1κ anti-glomerular basement membrane disease: a case report. Am J Kidney Dis 65:322–326CrossRefPubMedGoogle Scholar
  3. 3.
    Vankalakunti M, Nada R, Kumar A, Patro K, Ramakrishnan S, Rangarajan D (2017) Circulating monoclonal IgG1-kappa antibodies causing anti-glomerular basement membrane nephritis. Indian J Nephrol 27:327–329CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Fervenza FC, Terreros D, Boutaud A, Hudson BG, Williams RA Jr, Donadio JV Jr, Schwab TR (1999) Recurrent Goodpasture’s disease due to a monoclonal IgA-kappa circulating antibody. Am J Kidney Dis 34:549–555CrossRefPubMedGoogle Scholar
  5. 5.
    Savige JA, Yeung SP, Bierre AR, Kincaid-Smith P (1989) Lambda-light-chain-mediated anti-GBM disease. Nephron 52:144–148CrossRefPubMedGoogle Scholar
  6. 6.
    Nasr SH, Collins AB, Alexander MP, Schraith DF, Herrera Hernandez L, Fidler ME, Sethi S, Leung N, Fervenza FC, Cornell LD (2016) The clinicopathologic characteristics and outcome of atypical anti-glomerular basement membrane nephritis. Kidney Int 89:897–908CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Hematology DepartmentHospital del SalvadorSantiago de ChileChile
  2. 2.Nephrology DepartmentHospital del SalvadorSantiago de ChileChile
  3. 3.Pathology Department, Facultad de MedicinaPontificia Universidad CatólicaSantiago de ChileChile

Personalised recommendations