Lymphomatoid granulomatosis mimicking cancer and sarcoidosis
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Two cases of misdiagnoses of lymphomatoid granulomatosis are discussed here. Lymphomatoid granulomatosis is an Epstein-Barr virus-associated lymphoproliferative disorder with aggressive behavior. Due to its rarity and many presentations, delay in diagnosis and treatment is common. Its histological features including large atypical B-cells, T cell predominance, angiocentricity, necrosis, and evidence of EBV-positive cells should elicit the diagnosis of lymphomatoid granulomatosis. The settings that are described here have not yet been described in the literature.
KeywordsLymphomatoid granulomatosis Epstein-Barr virus Pulmonary nodules Misdiagnosis
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The authors declare that they have no conflict of interest.
- 3.Lipford EH Jr, Margolick JB, Longo DL, Fauci AS, Jaffe ES (1988) Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations. Blood 72:1674–1681Google Scholar
- 10.Fujimaki M, Kawajiri S, Ichikawa K, Tomizawa Y, Nakazato T, Noda K, Hattori N, Koike M, Okuma Y (2015) Lymphomatoid granulomatosis with central nervous system involvement successfully treated with cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab (CHASER therapy) followed by brain irradiation: a case study. CNS Neurosci Ther 21:610–612CrossRefGoogle Scholar