Annals of Hematology

, Volume 97, Issue 10, pp 1775–1783 | Cite as

Myeloid neoplasms with t(16;21)(q24;q22)/RUNX1-RUNX1T3 mimics acute myeloid leukemia with RUNX1-RUNX1T1

  • Huifei Liu
  • Sa A. Wang
  • Ellen J. Schlette
  • Jie Xu
  • Jeffrey L. Jorgensen
  • C. Cameron Yin
  • Shaoying Li
  • L. Jeffrey Medeiros
  • Guilin TangEmail author
Original Article


Chromosome translocation t(16;21)(q24;q22)/RUNX1-RUNX1T3 is an infrequent but recurrent chromosomal abnormality identified in myeloid neoplasms, with only 25 cases have been reported to date. Here, we report eight cases (six women and two men) of myeloid neoplasms associated with t(16;21)(q24;q22): five with therapy-related myeloid neoplasms, two with relapsed acute myeloid leukemia (AML), and one with blast phase of chronic myeloid leukemia. Morphologic and immunophenotypic features include granulocytic dysplasia, blasts with prominent perinuclear hof, large orange-pink granules, long and slim Auer rods, and aberrant expression of CD19. Six patients received AML-based regimens, and five achieved complete remission after initial induction therapy. Our study suggests that myeloid neoplasm with t(16;21)/RUNX1-RUNX1T1 resembles AML with t(8;21)(q22;q22)/RUNX1-RUNX1T1, in regard to morphology, immunophenotype, and response to therapy. Therefore, the clinical management of AML with t(8;21) may provide the best model for patients with myeloid neoplasms with t(16;21).


Myeloid neoplasms RUNX1/RUNX1T3 rearrangement t(16;21) Therapy-related 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Huifei Liu
    • 1
    • 2
  • Sa A. Wang
    • 1
  • Ellen J. Schlette
    • 1
  • Jie Xu
    • 1
  • Jeffrey L. Jorgensen
    • 1
  • C. Cameron Yin
    • 1
  • Shaoying Li
    • 1
  • L. Jeffrey Medeiros
    • 1
  • Guilin Tang
    • 1
    Email author
  1. 1.Department of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Hematologics, Inc.SeattleUSA

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