Annals of Hematology

, Volume 97, Issue 10, pp 1851–1857 | Cite as

Treating synchronous bilateral ocular adnexal marginal zone lymphoma: the consortium for improving survival of lymphoma study

  • Sung Yong Oh
  • Won Seog Kim
  • Hye-Jin Kang
  • Ji Hyun Lee
  • Seok Jae Huh
  • Seok Jin Kim
  • Dok Hyun Yoon
  • Jung Yong Hong
  • Won Sik Lee
  • Hyo Jung Kim
  • Jong Ho Won
  • Byeong-Bae Park
  • Soon II Lee
  • Cheolwon SuhEmail author
Original Article


Both-side synchronous involvement has been reported to account for 7–24% of ocular adnexal marginal zone lymphoma (OAML). We conducted a retrospective analysis to identify the clinical features and treatment outcomes of synchronous bilateral OAML (SB-OAML) by treatment modality. We analyzed patients with a histologic diagnosis of SB-OAML, excluding metachronous bilateral involved OAML. We enrolled a total of 95 patients for this analysis, 36 males and 59 females; the median patient age was 42 years (range 16–77 years). Eleven (11.6%) patients had been treated with chemotherapy or chemo-immunotherapy (eight R-CVP, two CVP, and one R-CHOP). The median number of treatments was 6 (range 6–8); there were 9 complete responses (CRs; 81.8%) and 2 partial responses (PRs; 18.2%). Nearly all patients (88.4%) received radiotherapy in both eyes, and the median radiation dose was 27 Gy (range 20–40 Gy) to each eye; 68 CRs (80.9%) and 14 PRs (16.7%) were achieved. Ten-year progression-free survival (PFS) and overall survival (OS) rates were 79.8 and 91.1%, respectively. Radiotherapy continued to be an independent prognostic marker, with the hazard of progression (P = 0.036). Eleven patients (13.1%) had surgery for cataract treatment during follow-up, and patients who received low-dose radiation (< 30.3 Gy) experienced fewer cataract operations. SB-OAML was predominantly observed in young females, and they had good response and prognosis regardless of treatment modalities. Low-dose radiotherapy to both eyes showed a tendency of longer PFS than did chemotherapy and could decrease cataract operations.


Ocular adnexal marginal zone lymphoma Synchronous Bilateral 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Sung Yong Oh
    • 1
  • Won Seog Kim
    • 2
  • Hye-Jin Kang
    • 3
  • Ji Hyun Lee
    • 1
  • Seok Jae Huh
    • 1
  • Seok Jin Kim
    • 2
  • Dok Hyun Yoon
    • 4
  • Jung Yong Hong
    • 4
  • Won Sik Lee
    • 5
  • Hyo Jung Kim
    • 6
  • Jong Ho Won
    • 7
  • Byeong-Bae Park
    • 8
  • Soon II Lee
    • 9
  • Cheolwon Suh
    • 4
    • 10
    Email author
  1. 1.Department of Internal MedicineDong-A University HospitalBusanSouth Korea
  2. 2.Department of Medicine, Samsung Medical CenterSunkyunkwan University School of MedicineSeoulSouth Korea
  3. 3.Division of Hematology/Oncology, Department of Internal Medicine, Korea Cancer Center HospitalKorea Institute of Radiological and Medical SciencesSeoulSouth Korea
  4. 4.Department of Oncology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea
  5. 5.Department of Hematology, Busan Paik HospitalInje University College of MedicineBusanSouth Korea
  6. 6.Department of Internal Medicine, Hallym University Sacred Heart HospitalHallym University College of MedicineSeoulSouth Korea
  7. 7.Department of Internal Medicine, Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoulSouth Korea
  8. 8.Division of Hematology/Oncology, Department of Internal MedicineHanyang University College of MedicineSeoulSouth Korea
  9. 9.Department of Internal MedicineDankook University College of MedicineCheonanSouth Korea
  10. 10.Department of Hematology–OncologyAsan Medical Center University of Ulsan College of MedicineSongpa-guSouth Korea

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