Chronic lymphocytic leukemia international prognostic index (CLL-IPI) in patients receiving chemoimmuno or targeted therapy: a systematic review and meta-analysis
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The chronic lymphocytic leukemia international prognostic index (CLL-IPI) which incorporates five parameters (age, clinical stage, TP53 status (normal vs. del (17p) and/or TP53 mutation), IGHV mutational status, and serum β2-microglobulin) was first proposed in 2016 by CLL-IPI working group to predict clinical outcome in CLL patients . The validity of the CLL-IPI has been confirmed across several series including patients mostly treated with chemotherapy or chemoimmunotherapy (CIT) [2, 3, 4, 5, 6, 7, 8]. However, the index was specifically developed from large cohorts of younger patients (median age, 61 years) participating in clinical trials testing chemotherapy or CIT. Therefore, the universal value of CLL-IPI in elderly/unfit patients suitable for CIT or B cell receptor inhibitor therapy given in front-line or for relapsed/refractory (R/R) disease is unclear.
These considerations led us to conduct a systematic review and meta-analysis restricted to published studies...
SM designed the study, selected and evaluated studies, performed data extraction, evaluated and interpreted results, and wrote the manuscript; DG selected and evaluated studies, performed data extraction, performed statistical analyses, and evaluated results; TDS evaluated and interpreted results the paper; RM and LL interpreted results; and all authors reviewed and approved the manuscript.
Compliance with ethical standards
Conflict of interest disclosure
The authors declare that they have no conflict of interest.
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