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Annals of Hematology

, Volume 97, Issue 9, pp 1601–1609 | Cite as

Allogeneic stem cell transplantation recipients requiring intensive care: time is of the essence

  • Corentin Orvain
  • Francois Beloncle
  • Jean-Francois Hamel
  • Aurélien Sutra Del Galy
  • Sylvain Thépot
  • Mélanie Mercier
  • Achille Kouatchet
  • Jonathan Farhi
  • Sylvie Francois
  • Norbert Ifrah
  • Alain Mercat
  • Pierre Asfar
  • Mathilde Hunault-Berger
  • Aline Tanguy-Schmidt
Original Article

Abstract

The benefit of early admission of allogeneic stem cell transplantation (SCT) recipients to the intensive care unit (ICU) as soon as they develop organ injury is unknown. We performed a retrospective study on 92 patients admitted to the ICU to determine the impact of time from organ injury to ICU admission on outcome. The number of organ injuries prior to ICU admission was associated with an increased in-hospital mortality (OR 1.7, 95% CI 1–2.7, p = 0.04). Time between first organ injury and ICU admission was also associated with an increased in-hospital survival (OR 1.4, 95% CI 1.1–1.8, p = 0.02). A score combining these two covariates—the number of organ injuries/day (sum of days spent with each individual organ injury)—further improved the prediction of hospital survival. Patients with more organ injuries/day had significantly higher in-hospital mortality rate even after adjustment for refractory acute GVHD and the SOFA (OR 1.3, 95% CI 1–1.7, p = 0.02). Early ICU admission of allogeneic SCT recipients to the ICU as soon as they develop organ injury is associated with decreased in-hospital mortality.

Keywords

Allogeneic stem cell transplantation (SCT) Intensive care unit (ICU) Early admission 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

277_2018_3320_MOESM1_ESM.docx (351 kb)
ESM 1 (DOCX 350 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Corentin Orvain
    • 1
    • 2
    • 3
  • Francois Beloncle
    • 4
  • Jean-Francois Hamel
    • 5
  • Aurélien Sutra Del Galy
    • 1
  • Sylvain Thépot
    • 1
  • Mélanie Mercier
    • 1
  • Achille Kouatchet
    • 4
  • Jonathan Farhi
    • 1
  • Sylvie Francois
    • 1
  • Norbert Ifrah
    • 1
    • 2
    • 3
  • Alain Mercat
    • 4
  • Pierre Asfar
    • 4
  • Mathilde Hunault-Berger
    • 1
    • 2
    • 3
  • Aline Tanguy-Schmidt
    • 1
    • 2
    • 3
  1. 1.Maladies du SangCHU d’AngersAngers CedexFrance
  2. 2.CRCINA, INSERM, Université de Nantes, Université d’AngersAngersFrance
  3. 3.FHU GOALAngersFrance
  4. 4.Réanimation MédicaleCHU d’AngersAngersFrance
  5. 5.Centre de Recherche CliniqueCHU d’AngersAngersFrance

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