Impact of hematopoietic stem cell transplantation in patients with relapsed or refractory mantle cell lymphoma

  • Satoshi Yamasaki
  • Dai Chihara
  • Sung-Won Kim
  • Koji Izutsu
  • Kouji Iwato
  • Takahiro Fukuda
  • Naoyuki Uchida
  • Itsuto Amano
  • Hideyuki Nakazawa
  • Junya Kuroda
  • Hisako Hashimoto
  • Tatsuo Ichinohe
  • Yoshinobu Kanda
  • Yoshiko Atsuta
  • Junji Suzumiya
  • Ritsuro Suzuki
Original Article
  • 106 Downloads

Abstract

Rituximab has been shown to improve outcomes in patients with B-cell lymphoma. However, patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) still have a poor prognosis, and the choice between high-dose therapy with autologous hematopoietic cell transplantation (HCT) and allogeneic HCT remains controversial in these patients. We retrospectively analyzed the risk factors for outcomes in 162 R/R MCL patients who received autologous (n = 111) or allogeneic (n = 51) HCT between 2004 and 2014. The median overall survival (OS) rates were 48 and 65 months in the autologous and allogeneic HCT groups, respectively (P = 0.20). Significant risk factors for overall survival in R/R MCL patients after autologous HCT were > 60 years of age at HCT (P = 0.017), higher score of HCT-specific comorbidity index at HCT (P = 0.033), and receiving MCEC (ranimustine + carboplatin + etoposide + cyclophosphamide) regimen (P = 0.017), while higher performance status at HCT (P = 0.011) and longer interval from diagnosis to HCT (P = 0.0054) were risk factors after allogeneic HCT. Strategies that carefully select R/R MCL patients for autologous HCT may allow the identification of individuals suitable for allogeneic HCT.

Keywords

Mantle cell lymphoma Autologous hematopoietic cell transplantation Allogeneic hematopoietic cell transplantation relapsed or refractory 

Notes

Acknowledgements

We appreciate the patients and clinical staff for their participation in the study. We are very grateful to the Japanese Data Center for Hematopoietic Cell Transplantation for data management and to the Clinical Research Institute of Kyushu Medical Hospital for their editorial support. The Practical Research Project for Allergic Diseases and Immunology (Research Technology of Medical Transplantation) of the Japan Agency for Medical Research and Development (AMED) supported this work. We thank Edanz Group (www.edanzediting.com) for editing a draft of this manuscript.

Compliance with ethical standards

This study was approved by the data management committee of the Japanese Society for Hematopoietic Cell Transplantation and the Institutional Review Board of Kyushu Medical Center.

Informed consent

The TRUMP databese includes physician-reviewed data. Observational studies base on the TRUMP databese are performed with an informed consent.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Satoshi Yamasaki
    • 1
  • Dai Chihara
    • 2
  • Sung-Won Kim
    • 3
  • Koji Izutsu
    • 4
  • Kouji Iwato
    • 5
  • Takahiro Fukuda
    • 3
  • Naoyuki Uchida
    • 4
  • Itsuto Amano
    • 6
  • Hideyuki Nakazawa
    • 7
  • Junya Kuroda
    • 8
  • Hisako Hashimoto
    • 9
  • Tatsuo Ichinohe
    • 10
  • Yoshinobu Kanda
    • 11
  • Yoshiko Atsuta
    • 12
  • Junji Suzumiya
    • 13
  • Ritsuro Suzuki
    • 13
  1. 1.Department of Hematology and Clinical Research InstituteNational Hospital Organization Kyushu Medical CenterFukuokaJapan
  2. 2.Department of Internal MedicineThe University of New MexicoAlbuquerqueUSA
  3. 3.Division of Hematopoietic Stem Cell TransplantationNational Cancer Center HospitalTokyoJapan
  4. 4.Department of HematologyFederation of National Public Service Personnel Mutual Aid Associations Toranomon HospitalTokyoJapan
  5. 5.Department of HematologyHiroshima Red Cross Hospital and Atomic-bomb Survivors HospitalHiroshimaJapan
  6. 6.Department of Respiratory, Allergy, and HematologyNara Medical University HospitalNaraJapan
  7. 7.Division of Hematology, Department of Internal MedicineShinshu University School of MedicineMatsumotoJapan
  8. 8.Division of Hematology and Oncology, Department of MedicineKyoto Prefectural University of MedicineKyotoJapan
  9. 9.Department of Hematology and Cell therapyKobe General Hospital and Institute of Biomedical Research and InnovationKobeJapan
  10. 10.Department of Hematology and Oncology, Research Institute for Radiation Biology and MedicineHiroshima UniversityHiroshimaJapan
  11. 11.Division of Hematology, Saitama Medical CenterJichi Medical UniversitySaitamaJapan
  12. 12.Department of Healthcare AdministrationNagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell TransplantationNagoyaJapan
  13. 13.Department of Oncology and HematologyShimane University HospitalIzumoJapan

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