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Health-related quality of life in Korean lymphoma survivors compared with the general population

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Abstract

The objective of this study was to evaluate the health-related quality of life (HRQOL) of lymphoma survivors, to compare it with that of the general population, and to identify its predictors in lymphoma survivors. We enrolled 837 participants (mean age, 54.6 years; mean time since diagnosis, 6.3 years) with a history of Hodgkin’s lymphoma (HL) (n = 58) or non-Hodgkin’s lymphoma (NHL) (n = 779) who had been treated at any of three Korean hospitals from 1989 through 2010. For controls, we selected 1,000 subjects randomly from a representative Korean population. We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and the Hospital Anxiety and Depression Scale. Overall, the HRQOL in both groups of survivors and the general population were comparable, but we observed clinically meaningful worse social functioning in NHL survivors (p < 0.001) and more severe fatigue in HL survivors (p < 0.001) than in the general population. Analysis of covariance revealed no clinically meaningful difference in HRQOL associated with age or sex. Survivors who received peripheral blood stem cell transplants showed clinically meaningful worse role (p = 0.001) and social (p < 0.001) functioning than those who were treated with first-line chemotherapy alone. In multivariate analyses, fatigue, depression, and financial difficulties emerged as the strongest predictors for almost all subscales of functioning and global quality of life. Interventions for alleviating fatigue, depression, and financial difficulties are needed to enhance the HRQOL of Korean lymphoma survivors.

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Acknowledgments

This study was supported by Inha University Research Grant. Miriam Bloom (SciWrite Biomedical Writing and Editing Services) provided professional English-language editing.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Nursing, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon, 410-742, South Korea

    Soo Hyun Kim

  2. Cancer Education Center, Samsung Comprehensive Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Im-Ryung Kim

  3. Cancer Education Center, Asan Medical Center, Seoul, South Korea

    So Hee Kim

  4. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Suyeon Lee & Cheolwon Suh

  5. Division of Hematology–Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Onam Ok & Won Seog Kim

  6. Hemato-Oncology Division, Inha University Hospital and College of Medicine, Incheon, South Korea

    Moon Hee Lee

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  1. Soo Hyun Kim
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Correspondence to Soo Hyun Kim.

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Kim, S.H., Kim, IR., Kim, S.H. et al. Health-related quality of life in Korean lymphoma survivors compared with the general population. Ann Hematol 93, 1531–1540 (2014). https://doi.org/10.1007/s00277-014-2091-3

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  • DOI: https://doi.org/10.1007/s00277-014-2091-3

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