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Assessment of the Antithrombogenicity of a Poly-2-Methoxyethylacrylate-Coated Central Venous Port-Catheter System

Abstract

Purpose

The purpose of this study was to evaluate the antithrombogenic effects of poly-2-methoxyethylacrylate (PMEA) coating applied to the internal surfaces of the port-catheter system to prevent thrombotic occlusion.

Materials and Methods

PMEA coating was applied to the inner surfaces of the entire system, including the chamber, catheter, and connecting stem. PMEA-coated and uncoated port-catheter systems were each filled with fresh human blood for 1 or 3 h and then flushed with saline. Volumes of residual thrombi in the system and protein in the catheter were then compared.

Results

Saline flushing of the PMEA-coated port-catheter system expelled all visually recognizable thrombi, leaving no unremovable adhesions. In contrast, the uncoated port showed thrombi adherent to the inner surfaces and incomplete expulsion with flushing. Mean (± standard deviation) residual thrombus mass was significantly lower in PMEA-coated port-catheter systems (20.5 ± 6.2 mg) than in uncoated systems (230.3 ± 92.5 mg; p < 0.01). Mean residual protein was likewise significantly lower in PMEA-coated systems (20.5 ± 6.2 mg) than in uncoated systems (230.3 ± 92.5 mg; p < 0.01).

Conclusions

PMEA coating on a central venous port-catheter system decreased accumulation and facilitated flushing of thrombi from the system by flushing, as compared with the uncoated system. PMEA-coated central venous port-catheter systems appear relatively antithrombotic compared to uncoated systems.

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Author information

Correspondence to Shuji Kariya.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

Our institutional review board approved the study (Approval No. #2017110). Six healthy volunteers participated in this study. The study protocols for this retrospective analysis were approved by our institutional review board.

Informed Consent

Informed consent was obtained from each volunteer prior to participation in the study.

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Kariya, S., Nakatani, M., Ono, Y. et al. Assessment of the Antithrombogenicity of a Poly-2-Methoxyethylacrylate-Coated Central Venous Port-Catheter System. Cardiovasc Intervent Radiol (2020). https://doi.org/10.1007/s00270-020-02408-6

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Keywords

  • Port
  • Poly-2-methoxyethylacrylate
  • Antithrombogenicity
  • Complication
  • Thrombosis
  • Coating