CardioVascular and Interventional Radiology

, Volume 41, Issue 11, pp 1654–1663 | Cite as

Ultrasound Evaluation of Puncture Sites After Deployment of Two Different Types of Vascular Closure Devices: A Prospective Comparative Study

  • Young Jin Heo
  • Hae Woong JeongEmail author
  • Jin Wook Baek
  • Sun Joo Lee
  • Hye Jung Choo
  • Hyun Seok Jung
  • Gi Won Shin
  • Jung Hwa Seo
  • Sung Tae Kim
Clinical Investigation Arterial Interventions
Part of the following topical collections:
  1. Arterial Interventions



The aim of this study was to compare the ultrasonographic findings of femoral puncture sites and the complications of Perclose ProGlide® and FemoSeal™ after neurointerventional procedures.


In this prospective, single-center study, we randomly assigned 155 femoral puncture sites to treatment with Perclose ProGlide® or FemoSeal™. We hypothesized that the two different types of VCD cause different vascular changes. Ultrasonography of the femoral puncture sites was performed 24 h after the procedure and at an outpatient visit after 6 months. The intima–media thickness (IMT), vessel diameter, and minimal luminal diameter of the common femoral artery were measured; the perivascular soft tissue change and absorption of the hemostatic material were observed. The device failure rate and vascular complications associated with each device were also evaluated.


Follow-up ultrasonography was performed at a median follow-up time of 187.0 days (range 147–240 days) after the initial ultrasonography. The IMT on follow-up ultrasonography was significantly higher in patients who received FemoSeal™ (P = 0.0000). Intimal hyperplasia and partial absorption of the hemostatic material were significantly more frequent in patients who received FemoSeal™. The vessel diameters on initial and follow-up ultrasonography were not significantly different, but the minimal diameter on follow-up ultrasonography was significantly lower in patients who received FemoSeal™. Device failure and pseudoaneurysms occurred at 9 and 3 puncture sites in patients who received Perclose ProGlide®, respectively.


Intimal hyperplasia was more frequently observed in patients who received FemoSeal™. However, more device failures and pseudoaneurysms occurred in patients who received Perclose ProGlide®.

Level of Evidence

Step 2 (level 2).


Vascular closure device FemoSeal Perclose ProGlide Ultrasonography Intima–media thickness Intimal hyperplasia 



This study was funded by Abbott Vascular Korea.

Compliance with Ethical Standards

Conflict of interest

The authors do not have any conflicts of interest to declare.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in this study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018

Authors and Affiliations

  • Young Jin Heo
    • 1
  • Hae Woong Jeong
    • 1
    Email author
  • Jin Wook Baek
    • 1
  • Sun Joo Lee
    • 1
  • Hye Jung Choo
    • 1
  • Hyun Seok Jung
    • 1
  • Gi Won Shin
    • 1
  • Jung Hwa Seo
    • 2
  • Sung Tae Kim
    • 3
  1. 1.Department of RadiologyInje University Busan Paik HospitalBusanKorea
  2. 2.Department of NeurologyInje University Busan Paik HospitalBusanKorea
  3. 3.Department of NeurosurgeryInje University Busan Paik HospitalBusanKorea

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