CardioVascular and Interventional Radiology

, Volume 41, Issue 11, pp 1799–1802 | Cite as

Y-90 Radioembolization Combined with a PD-1 Inhibitor for Advanced Hepatocellular Carcinoma

  • Eric Wehrenberg-Klee
  • Lipika Goyal
  • Matthew Dugan
  • Andrew X. Zhu
  • Suvranu GanguliEmail author
Case Report


Nivolumab has recently received approval by the Food and Drug Administration for treatment of advanced hepatocellular carcinoma (HCC) in patients previously treated with sorafenib. Nivolumabs’ overall response rate of 20% (El-Khoueiry et al. in Lancet 389:2492–2502, 2017) is a step forward for these patients, but there is significant room for improvement. We describe a case of combining Y-90 radioembolization with nivolumab for treatment of angioinvasive HCC, which successfully bridged patient to partial hepatectomy. Surgical pathology showed negative margins with complete pathological response. With the introduction of immunotherapy for HCC, combining Y-90 radioembolization with immunotherapy may enhance the anti-tumoral immune response of checkpoint inhibitors.


Radioembolization Hepatocellular carcinoma Immunotherapy Y-90 Nivolumab Checkpoint inhibitors 


Compliance with Ethical Standards

Conflict of interest

Suvranu Ganguli is a proctor for SIRTEX medical. The other authors have no conflicts of interest.

Consent for Publication

Consent for publication was obtained for every individual person’s data including the study.

Ethical Approval and Informed Consent

This study has obtained IRB approval from the Massachusetts General Hospital IRB and the need for informed consent was waived.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018

Authors and Affiliations

  • Eric Wehrenberg-Klee
    • 1
  • Lipika Goyal
    • 2
  • Matthew Dugan
    • 3
  • Andrew X. Zhu
    • 2
  • Suvranu Ganguli
    • 1
    Email author
  1. 1.Department of RadiologyMassachusetts General HospitalBostonUSA
  2. 2.Massachusetts General Hospital Cancer CenterBostonUSA
  3. 3.New England Cancer Care SpecialistsScarboroughUSA

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