In Vivo Proof of Superselective Transarterial Chemoembolization with 40-μm Drug-Eluting Beads in a Patient with Hepatocellular Carcinoma
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Transarterial chemoembolization (TACE) is the current standard of care in patients with hepatocellular carcinoma (HCC) when curative therapies, including hepatic resection, image-guided ablation, or liver transplantation, are precluded. In the multicenter PRECISION V study comparing conventional lipiodol-based TACE with drug-eluting bead TACE (DEB-TACE) in patients with intermediate-stage HCC, DEB-TACE was associated with lesser cardiac and hepatic toxicity although no superior survival benefit was confirmed . In choosing the optimal size of DEB, the use of 100–300-μm DEB is generally recommended since this is the most commonly available size, but there is still relatively lack of comparative data on the optimal size of the beads. Recently, drug-eluting beads with a diameter of 40 ± 10 μm have been introduced. Theoretically, smaller beads penetrate deeper within a tumor allowing more effective drug delivery. We report a case of TACE with 40-μm beads in a patient with...
KeywordsTace Pulmonary Uptake Conventional Tace Subsegmental Artery Lipiodol Emulsion
Conflict of interest
All authors (Hoi Lam SHE, Mark Christiaan BURGMANS, Minneke COENRAADM, and Arantza Farina SARAQUETA) have no real or perceived conflict of interest to disclose.
Statement of Informed Consent
The current study is performed in accordance to the institution ethic review board, and medical ethical approval is not required in our institution for anonymized case report.
- 2.Lee KH, Liapi E, Vossen JA, et al. Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy. J Vasc Interv Radiol. 2008;19(10):1490–6.PubMedPubMedCentralCrossRefGoogle Scholar
- 5.Kwan SW, Fidelman N, Ma E, Kerlan RK Jr, Yao FY. Imaging predictors of the response to transarterial chemoembolization in patients with hepatocellular carcinoma: a radiological-pathological correlation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2012;18(6):727–36.CrossRefGoogle Scholar