CardioVascular and Interventional Radiology

, Volume 39, Issue 1, pp 137–140 | Cite as

In Vivo Proof of Superselective Transarterial Chemoembolization with 40-μm Drug-Eluting Beads in a Patient with Hepatocellular Carcinoma

  • Hoi Lam SheEmail author
  • Mark Christiaan Burgmans
  • Minneke Coenraadm
  • Arantza Farina Saraqueta
Brief Communication


Transarterial chemoembolization (TACE) is the current standard of care in patients with hepatocellular carcinoma (HCC) when curative therapies, including hepatic resection, image-guided ablation, or liver transplantation, are precluded. In the multicenter PRECISION V study comparing conventional lipiodol-based TACE with drug-eluting bead TACE (DEB-TACE) in patients with intermediate-stage HCC, DEB-TACE was associated with lesser cardiac and hepatic toxicity although no superior survival benefit was confirmed [1]. In choosing the optimal size of DEB, the use of 100–300-μm DEB is generally recommended since this is the most commonly available size, but there is still relatively lack of comparative data on the optimal size of the beads. Recently, drug-eluting beads with a diameter of 40 ± 10 μm have been introduced. Theoretically, smaller beads penetrate deeper within a tumor allowing more effective drug delivery. We report a case of TACE with 40-μm beads in a patient with...


Tace Pulmonary Uptake Conventional Tace Subsegmental Artery Lipiodol Emulsion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

All authors (Hoi Lam SHE, Mark Christiaan BURGMANS, Minneke COENRAADM, and Arantza Farina SARAQUETA) have no real or perceived conflict of interest to disclose.

Statement of Informed Consent

The current study is performed in accordance to the institution ethic review board, and medical ethical approval is not required in our institution for anonymized case report.


  1. 1.
    Lammer J, Malagari K, Vogl T, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc Interv Radiol. 2010;33(1):41–52.CrossRefGoogle Scholar
  2. 2.
    Lee KH, Liapi E, Vossen JA, et al. Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy. J Vasc Interv Radiol. 2008;19(10):1490–6.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    de Baere T, Zhang X, Aubert B, et al. Quantification of tumor uptake of iodized oils and emulsions of iodized oils: experimental study. Radiology. 1996;201(3):731–5.PubMedCrossRefGoogle Scholar
  4. 4.
    Tanaka T, Nishiofuku H, Hukuoka Y, et al. Pharmacokinetics and antitumor efficacy of chemoembolization using 40 microm irinotecan-loaded microspheres in a rabbit liver tumor model. J Vasc Interv Radiol. 2014;25(7):1037–44.PubMedCrossRefGoogle Scholar
  5. 5.
    Kwan SW, Fidelman N, Ma E, Kerlan RK Jr, Yao FY. Imaging predictors of the response to transarterial chemoembolization in patients with hepatocellular carcinoma: a radiological-pathological correlation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2012;18(6):727–36.CrossRefGoogle Scholar
  6. 6.
    Sonomura T, Yamada R, Kishi K, Nishida N, Yang RJ, Sato M. Dependency of tissue necrosis on gelatin sponge particle size after canine hepatic artery embolization. Cardiovasc Interv Radiol. 1997;20(1):50–3.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2015

Authors and Affiliations

  • Hoi Lam She
    • 1
    Email author
  • Mark Christiaan Burgmans
    • 2
  • Minneke Coenraadm
    • 3
  • Arantza Farina Saraqueta
    • 4
  1. 1.Department of RadiologyPrincess Margaret HospitalKowloonHong Kong
  2. 2.Department of RadiologyLeiden University Medical CenterLeidenThe Netherlands
  3. 3.Department of Gastroenterology and HepatologyLeiden University Medical CenterLeidenThe Netherlands
  4. 4.Department of PathologyLeiden University Medical CentreLeidenThe Netherlands

Personalised recommendations