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Prognostic Impact of Tumor Doubling Time in Patients with Metachronous Lung Cancer

  • Keisuke AsakuraEmail author
  • Yukihiro Yoshida
  • Hiroyuki Sakurai
  • Kazuo Nakagawa
  • Noriko Motoi
  • Shun-ichi Watanabe
Original Scientific Report
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Abstract

Background

Good prognosis following surgery for metachronous lung cancer has been reported. However, prognostic factors have not been fully investigated. The purpose of this study was to identify the preoperative predictor of survival in metachronous lung cancer.

Methods

Patients who underwent a second pulmonary resection for metachronous lung cancer at our institution between 2000 and 2014 were analyzed.

Results

A retrospective chart review identified 86 eligible patients (of 6213; 1.4%). The 5-year overall survival was 77%. All 86 cancers met Martini and Melamed’s criteria for second primary cancer. However, on pathological examination based on morphological concordance between the initial and metachronous cancer, 73 (85%) cases were diagnosed as second primary cancer and 13 (15%) as a possible recurrent tumor. The 5-year overall survivals were 82% for second primary cancers and 52% for possible recurrent tumors. Tumor doubling time > 180 days (p < 0.001), pathological diagnosis of second primary cancer (p = 0.013), pathological stage IA (p = 0.016), interval between resections > 2 years (p = 0.040), and consolidation/tumor diameter ratio ≤ 0.5 (p = 0.045) were associated with superior overall survival. Multivariate Cox regression analysis identified tumor doubling time > 180 days as the only independent predictor of overall survival (hazard ratio 3.600, 95% confidence interval 1.226–10.338; p = 0.0196).

Conclusions

Surgical resection for metachronous lung cancer is effective and feasible. Particularly, a tumor doubling time > 180 days is associated with superior survival in patients with metachronous lung cancer.

Notes

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

The Institutional Ethical Committee approved the study and waived the need for individual patients to provide consent because of the retrospective nature of the study, because consent could not be obtained from all of the patients, and because individual patients were not identified in the study.

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Copyright information

© Société Internationale de Chirurgie 2019

Authors and Affiliations

  • Keisuke Asakura
    • 1
    • 2
    Email author
  • Yukihiro Yoshida
    • 1
  • Hiroyuki Sakurai
    • 1
    • 3
  • Kazuo Nakagawa
    • 1
  • Noriko Motoi
    • 4
  • Shun-ichi Watanabe
    • 1
  1. 1.Department of Thoracic SurgeryNational Cancer Center HospitalTokyoJapan
  2. 2.Division of Thoracic SurgeryKeio University School of MedicineTokyoJapan
  3. 3.Division of Respiratory SurgeryNihon University School of MedicineTokyoJapan
  4. 4.Department of Pathology and Clinical LaboratoriesNational Cancer Center HospitalTokyoJapan

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