Early Acute Kidney Injury Within an Established Enhanced Recovery Pathway: Uncommon and Transitory

  • Fabian Grass
  • Jenna K. Lovely
  • Jacopo Crippa
  • Kellie L. Mathis
  • Martin Hübner
  • David W. LarsonEmail author
Original Scientific Report



The present study aimed to assess the impact of perioperative fluid management on early acute kidney injury (AKI) rate and long-term sequelae in patients undergoing elective colorectal procedures within an enhanced recovery pathway (ERP).


Retrospective analysis of consecutive patients from a prospectively maintained ERP database (2011–2015) is performed. Pre- and postoperative creatinine levels (within 24 h) were compared according to risk (preoperative creatinine rise ×1.5), injury (×2), failure (×3), loss of kidney function and end-stage kidney disease (RIFLE) criteria. Risk factors for early AKI were identified through logistic regression analysis, and long-term outcome in patients with AKI was assessed.


Out of 7103 patients, 4096 patients (58%) with pre- and postoperative creatinine levels were included. Of these, 104 patients (2.5%) presented postoperative AKI. AKI patients received higher amounts of POD 0 fluids (3.8 ± 2.4 vs. 3.2 ± 2 L, p = 0.01) and had increased postoperative weight gain at POD 2 (6 ± 4.9 vs. 3 ± 2.7 kg, p = 0.007). Independent risk factors for AKI were high ASA score (ASA ≥ 3: OR 1.7; 95% CI 1.1–2.5), prolonged operating time (>180 min: OR 1.9; 95% CI 1.3–2.9) and diabetes mellitus (OR 2.5; 95% CI 1.5–4), while minimally invasive surgery was a protective factor (OR 0.6; 95% CI 0.4–0.9). Five patients (0.1%) developed chronic kidney disease, and two of them needed dialysis after a mean follow-up of 33.7 ± 22.4 months.


Early AKI was very uncommon in the present cohort of colorectal surgery patients treated within an ERP, and long-term sequelae were exceptionally low.



Fabian Grass was supported by the Société Académique Vaudoise, Lausanne, Switzerland, and by the SICPA foundation, Lausanne, Switzerland.


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Copyright information

© Société Internationale de Chirurgie 2019

Authors and Affiliations

  1. 1.Division of Colon and Rectal SurgeryMayo ClinicRochesterUSA
  2. 2.Department of Visceral SurgeryLausanne University Hospital CHUVLausanneSwitzerland
  3. 3.Hospital Pharmacy ServicesMayo ClinicRochesterUSA

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