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World Journal of Surgery

, Volume 42, Issue 11, pp 3616–3623 | Cite as

Cribriform-Morular Variant of Papillary Thyroid Carcinoma: Clinical and Pathological Features of 30 Cases

  • Junko Akaishi
  • Tetsuo Kondo
  • Kiminori Sugino
  • Yuna Ogimi
  • Chie Masaki
  • Kiyomi Y. Hames
  • Tomonori Yabuta
  • Chisato Tomoda
  • Akifumi Suzuki
  • Kenichi Matsuzu
  • Takashi Uruno
  • Keiko Ohkuwa
  • Wataru Kitagawa
  • Mitsuji Nagahama
  • Ryohei Katoh
  • Koichi Ito
Original Scientific Report
  • 96 Downloads

Abstract

Background

Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is rare; it may occur in cases of familial adenomatous polyposis (FAP) or be sporadic. To clarify the clinicopathological features of CMV-PTC, the medical records of these patients were investigated retrospectively.

Materials and methods

Between 1979 and 2016, a total of 17,062 cases with PTC underwent initial surgery at Ito Hospital. Of these, 30 (0.2%) cases histologically diagnosed with CMV-PTC were reviewed.

Result

The patients were all women, with a mean age at the time of surgery of 24 years. Seven (23%) cases were thought to have FAP because they had colonic polyposis or a family history of FAP or APC gene mutation. The remaining 23 (77%) were thought to be sporadic. Multiple tumors were detected in 6 cases, with a solitary tumor in 24. One patient had lung metastasis at diagnosis. Eleven patients underwent total thyroidectomy or subtotal thyroidectomy, and 19 underwent lobectomy. Twenty-six (87%) patients underwent neck lymph node dissection. Three patients had tumor metastasis in central lymph nodes, but these were incidentally detected metastatic classical PTC (cPTC) based on histological examination. In this series, there were no cases of LN metastases of CMV-PTC. During a mean follow-up of 15 years, one patient had new cPTC in the remnant thyroid after initial surgery, and the other patients showed no signs of recurrence.

Conclusion

CMV-PTC occurred in young women, their long-term prognosis was excellent. Total thyroidectomy is recommended for FAP-associated CMV-PTC, but modified neck lymph node dissection is not necessary.

Notes

Acknowledgements

We thank Ms. Wakaba Iha, University of Yamanashi, for her excellent technical assistance.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest

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Copyright information

© Société Internationale de Chirurgie 2018

Authors and Affiliations

  • Junko Akaishi
    • 1
  • Tetsuo Kondo
    • 2
  • Kiminori Sugino
    • 1
  • Yuna Ogimi
    • 1
  • Chie Masaki
    • 1
  • Kiyomi Y. Hames
    • 1
  • Tomonori Yabuta
    • 1
  • Chisato Tomoda
    • 1
  • Akifumi Suzuki
    • 1
  • Kenichi Matsuzu
    • 1
  • Takashi Uruno
    • 1
  • Keiko Ohkuwa
    • 1
  • Wataru Kitagawa
    • 1
  • Mitsuji Nagahama
    • 1
  • Ryohei Katoh
    • 2
  • Koichi Ito
    • 1
  1. 1.Department of SurgeryIto HospitalTokyoJapan
  2. 2.Department of PathologyYamanashi HospitalYamanashiJapan

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