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Fatal Cerebral Infarction and Ophthalmic Artery Occlusion After Nasal Augmentation with Hyaluronic Acid—A Case Report and Review of Literature

  • Qing Yang
  • Binglun Lu
  • Ning Guo
  • Liang Li
  • Yanjun Wang
  • Xianjie MaEmail author
  • Yingjun SuEmail author
Case Report Non-Surgical Aesthetic

Abstract

Background

Cerebral infarction is a rare complication of hyaluronic acid (HA) filler injection, usually presenting with sudden increase in intracranial pressure and loss of vision.

Methods

A 40-year-old Asian woman in a coma was transferred to the emergency intensive care unit of Xijing Hospital, China, 48 h after nasal augmentation with HA. Magnetic resonance imaging indicated cerebral infarction and left optic nerve edema and ischemia. Magnetic resonance angiography did not reveal vessel embolism.

Results

The patient developed gastric ulceration, pulmonary infection, respiratory failure, and cerebral herniation, and died 6 days after the HA filler injection.

Conclusion

Facial cosmetic HA filler injection can cause devastating and even fatal complications.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Keywords

Cerebral infarction Hyaluronic acid Embolism 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors claim no conflict of interest in this study.

Ethical Approval

This retrospective study was approved by the Institutional Research Ethics Committee of Xijing Hospital (Approval No. KY20192122-C-1).

Informed Consent

Signed informed consent was obtained from the patient’s family representative.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2020

Authors and Affiliations

  1. 1.Department of Plastic and Reconstructive Surgery, Xijing HospitalFourth Military Medical UniversityXi’anChina
  2. 2.Department of Plastic and Reconstructive SurgeryChangan HospitalXi’anChina
  3. 3.Department of Radiology, Xijing HospitalFourth Military Medical UniversityXi’anChina
  4. 4.Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing HospitalFourth Military Medical UniversityXi’anChina
  5. 5.Department of Emergency Medicine, Xijing HospitalFourth Military Medical UniversityXi’anChina

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