A Meta-analysis of the Evidence for Assisted Therapy with Platelet-Rich Plasma for Atrophic Acne Scars

  • Tyng-Shiuan Hsieh
  • Wen-Kuan Chiu
  • Ten-Fang Yang
  • Hsian-Jenn Wang
  • Chiehfeng ChenEmail author
Original Article Non-Surgical Aesthetic



A number of studies have investigated the role of platelet-rich plasma (PRP) as an assisted therapy for atrophic acne scars. However, the results are diverse, and no up-to-date meta-analysis was found that exclusively examined atrophic acne scar treatment.


To perform a meta-analysis to assess improvements in the side effects of PRP and the effect of assisted therapy for atrophic acne scars.


This study followed PRISMA guidelines. A comprehensive search of the literature was carried out in September 2018 using the electronic databases of PubMed, EMBASE, MEDLINE, and the Cochrane Library.


Seven articles were included in this review. All of the studies published utilized PRP as additive therapy. The major therapies included fractional carbon laser therapy and microneedling. Five studies (249 participants) reported four degrees of improvement on an improvement scale (degrees 3 and 4 were considered improvement in this analysis). Four studies (200 participants) reported mean improvement scores. A significantly higher degree of improvement was shown in the PRP group compared to the control group (OR = 8.19; 95% CI 4.32–15.52; p < 0.00001), as well as better mean improvement score (WMD = 23.73; 95% CI 18.60–28.87; p < 0.00001).

Substantial heterogeneity was seen in the degree of improvement (I2 = 54% p = 0.07) and the mean improvement score (I2 = 75%; p = 0.008). There were overall fewer monitored side effects, including erythema and edema (in days), in the PRP groups; however, no significance was found.


This review shows that PRP is a useful assisted therapy for atrophic acne scars, which can achieve better improvement.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors


Meta-analysis Platelet-rich plasma Atrophic acne scars 



This work was supported by Taipei Medical University—Wan Fang Hospital under the Grant No. 108TMU-WFH-23.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest to disclose.

Human and Animals Rights Statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

For this type of study, informed consent is not required.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2019

Authors and Affiliations

  • Tyng-Shiuan Hsieh
    • 1
  • Wen-Kuan Chiu
    • 2
    • 3
  • Ten-Fang Yang
    • 3
    • 4
  • Hsian-Jenn Wang
    • 2
  • Chiehfeng Chen
    • 2
    • 5
    • 6
    • 7
    Email author
  1. 1.School of Medicine, College of MedicineTaipei Medical UniversityTaipeiTaiwan, ROC
  2. 2.Division of Plastic Surgery, Department of Surgery, Taipei Municipal Wanfang HospitalTaipei Medical UniversityTaipeiTaiwan, ROC
  3. 3.Department of Biological Science and TechnologyNational Chiao-Tung UniversityHsinchu CityTaiwan, ROC
  4. 4.Graduate Institute of Medical Informatics and CardiologyTaipei Medical University and HospitalTaipeiTaiwan, ROC
  5. 5.Department of Public Health, School of Medicine, College of MedicineTaipei Medical UniversityTaipeiTaiwan, ROC
  6. 6.Cochrane TaiwanTaipei Medical UniversityTaipeiTaiwan, ROC
  7. 7.Division of Plastic Surgery, Department of Surgery, Wan Fang Hospital, School of Medicine, College of MedicineTaipei Medical UniversityTaipei CityTaiwan, ROC

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