Several Opinions on Effects of Insulin, Metoprolol and Deferoxamine on Fat Graft Survival

  • Shengyang Jin
  • Ya Li
  • Ting Shang
  • Zuguang Hua
  • Facheng LiEmail author
Letter to the Editor

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We read with great interest the article entitled “Effects of Insulin, Metoprolol and Deferoxamine on Fat Graft Survival” by Okyay et al. [1] in Aesthetic Plastic Surgery. The authors found that the three drugs did not exert a significant influence on fat graft survival.

The fat grafts treated with three kinds of drugs and the control group were implanted into the back of the rat. We are concerned that implanting different drugs on the back of one rat would result in drug absorption by the body and interfere with other groups.

In this study, the inguinal fat pads were split into four nearly equal parts as grafts. However, there would be a larger contact area between the grafts and the drug if the grafts were dissected into small pieces. Both shredded fat grafts and fat mass transplantation have been reported in the literature [2, 3], whose outcome may be different.


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest to disclose.


  1. 1.
    Okyay MF, Kömürcü H, Bağhaki S et al (2019) Effects of insulin, metoprolol and deferoxamine on fat graft survival. Aesthet Plast Surg 43(3):845–852CrossRefGoogle Scholar
  2. 2.
    Liu K, Cai J, Li H et al (2018) The disturbed function of neutrophils at the early stage of fat grafting impairs long-term fat graft retention. Plast Reconstr Surg 142(5):1229–1238CrossRefGoogle Scholar
  3. 3.
    Shi N, Su Y, Guo S et al (2019) Improving the retention rate of fat grafts in recipient areas via botulinum toxin A treatment. Aesthet Surg J. Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2019

Authors and Affiliations

  • Shengyang Jin
    • 1
  • Ya Li
    • 1
  • Ting Shang
    • 1
  • Zuguang Hua
    • 2
  • Facheng Li
    • 1
    Email author
  1. 1.Plastic Surgery Hospital (Institute), Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijingPeople’s Republic of China
  2. 2.Ningbo No1 HospitalNingboPeople’s Republic of China

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