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Aesthetic Plastic Surgery

, Volume 43, Issue 4, pp 1071–1077 | Cite as

Effect of Polydeoxyribonucleotide on Chondrocutaneous Composite Grafts Survival

  • Jae Won Heo
  • Yong Hun Kim
  • Eon Su Kim
  • Sug Won Kim
  • Jiye KimEmail author
Original Article Basic Science/Experimental
  • 96 Downloads

Abstract

Background

A composite graft is considered the best choice for facial reconstruction because of proper texture, color, and simple surgical techniques. However, due to revascularization by the bridging phenomenon, it has limitations with unpredictable survival rates and can be applied only to small defects. Polydeoxyribonucleotide (PDRN) plays an important role in multiple vascular processes such as angiogenesis via production of a vascular endothelial growth factor and by providing an anti-inflammatory effect by reducing pro-inflammatory cytokines through the adenosine A2 receptor stimulation. Thus, here, we investigated PDRN as a supportive method to improve survival of composite grafts.

Methods

Chondrocutaneous composite grafts were applied to both ears of 20 New Zealand White rabbits. The grafts were then rotated and returned to their positions to prevent the original blood flow from the base of the grafts. On postoperative days 1, 3, 6, 9, and 12, PDRN was injected intradermally into the experimental group (20 ears) and normal saline was injected into the control group (20 ears) to exclude bias of pressure effect. After 12 days, graft survival and cutaneous blood flow were examined under laser speckle contrast imaging.

Results

Gross observation indicated that the graft viability in the PDRN group was significantly higher than that in the control group (p < 0.05). Through laser speckle contrast imaging, signal intensity increased from the periphery and progressed centrally with treatment.

Conclusion

Our findings suggest that PDRN may increase blood flow around at the base of the graft, restore the perfusion, and improve the survival of the composite grafts.

No Level Assigned

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Keywords

Polydeoxyribonucleotides Tissue transplantation Graft survival 

Notes

Funding

This work was supported (in part) by the Yonsei University miraeseondo project of 2017 (2017-52-0064).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights

The Animal Care and Experiment Committee of Yonsei Wonju University approved the experimental protocol.

Informed Consent

For this type of study, informed consent is not required.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2019

Authors and Affiliations

  1. 1.Department of Plastic and Reconstructive SurgeryWonju Severance Christian Hospital, Wonju College of Medicine, Yonsei UniversityWonju-siRepublic of Korea

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