Aesthetic Plastic Surgery

, Volume 43, Issue 4, pp 1095–1101 | Cite as

Comparative Evaluation of the Biodegradability and Wrinkle Reduction Efficacy of Human-Derived Collagen Filler and Hyaluronic Acid Filler

  • Jong Hwan Kim
  • Tae-Rin Kwon
  • Sung Woo Hong
  • Joon Seok
  • Jae Min Kim
  • Ji Yeon Hong
  • Sung Eun Lee
  • Sung Won Han
  • Beom Joon KimEmail author
Original Article Basic Science/Experimental



The development of fillers for wrinkle prevention is growing to meet rising demands to reduce the aging of skin.


In this experiment, we confirmed the effects of human collagen and hyaluronic acid filler biodegradation for wrinkle reduction using a photo-aging mouse model.

Materials and Methods

A total of 10 hairless mice (SKH1-Hrhr) were randomly divided into two groups and injected with hyaluronic acid and human-derived collagen filler. At 0, 2, 4, 8, and 12 weeks, PRIMOSlite®, folliscope, and MRI were used to evaluate the biodegradability of the fillers after the injections. We also studied the photo-aging mouse model for skin roughness and histological evaluation and confirmed that the filler injection had excellent anti-wrinkle effects.


Human-derived collagen fillers had excellent biodegradability compared to that of hyaluronic acid fillers. The skin surface roughness in the photo-aging mouse models was significantly reduced after injections of human-derived collagen filler.


Our results showed that the human-derived collagen filler had excellent biodegradability and effectively reduced wrinkle formation in a photo-aging mouse model.

No Level Assigned

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors


Collagen filler Ultraviolet Photo-aging Wrinkle reduction 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest to disclose.

Human and Animal Rights

All applicable institutional and/or national guidelines for the care and use of animals were followed.

Informed Consent

For this type of study, informed consent is not required.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2019

Authors and Affiliations

  1. 1.Department of Dermatology, Chung-Ang University College of MedicineChung-Ang University HospitalSeoulRepublic of Korea
  2. 2.Department of Medicine, Graduate SchoolChung-Ang UniversitySeoulKorea

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