Aesthetic Plastic Surgery

, Volume 43, Issue 1, pp 221–227 | Cite as

Correction of Tear Trough Deformity Using Autologous Fibroblast Combined with Keratin: New Soft Tissue Filler

  • Wenshan Xing
  • Chen ZhangEmail author
  • Jiao Zhang
  • Qingguo ZhangEmail author
Original Article Non-Surgical Aesthetic



To evaluate the effectiveness and safety of autologous fibroblasts combined with keratin gel for tear trough deformity rectification as injectable soft tissue filler.

Materials and Methods

The new injectable soft tissue filler was derived from autologous fibroblasts and keratin gel. A total of 35 patients received treatment of this filler injection for tear trough deformity rectification. All the patients were followed up, and the clinical features including photographs and satisfaction were collected and assessed at 1, 3, 6, 12 and 24 months after injection. The efficacy of each patient was evaluated independently by blinded evaluators at different time points. All patients consented to publish identifiable photographs in this study.


Tear trough deformity was improved even at 18–24 months post-injection. No severe adverse effects were observed resulting from the filler injection.


Combination of autologous fibroblasts and keratin is efficient and safe for correction of the tear trough deformity with long-term satisfaction and desirable result.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors


Esthetics Blepharoplasty Fibroblasts Keratins 


Author Contributions

WX, CZ and JZ participated in the clinical application of the technique and the follow-up of the patients and analysis of data for the work. All authors participated drafted the article. QZ contributed the conception and design of the study and revised it critically for important intellectual content. All the authors approved the version to be submitted.


The article was sponsored by National Natural Science Foundation of China (Nos. 81571924, 31671312).

Compliance with Ethical Standards

Conflict of interest

The authors report no financial and personal relationships with other people or organizations that could inappropriately influence the work.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2018

Authors and Affiliations

  1. 1.Auricular Plastic and Reconstructive Surgery Center, Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingPeople’s Republic of China
  2. 2.Center of Clinical Laboratory Medicine of Zhongda HospitalSoutheast UniversityNanjingPeople’s Republic of China

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