Aesthetic Plastic Surgery

, Volume 43, Issue 2, pp 457–469 | Cite as

Problems and Solutions for Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Review

  • Xiaoxuan Lei
  • Pengcheng Xu
  • Biao ChengEmail author
Original Article Non-Surgical Aesthetic



In recent years, platelet-rich plasma (PRP) has been widely applied in orthopedics, maxillofacial surgery, burns, and plastic surgery, especially in facial rejuvenation. Research is ongoing into new indications and mechanisms of PRP to promote its wider, safer, and more effective use in the clinic. This article reviews the possible mechanisms of PRP in facial rejuvenation and related research. It is expected that the application of PRP in this field will increase.


The use of PRP in facial rejuvenation was screened using inclusion and exclusion criteria. The relevant articles were searched through Pubmed digest database, SCI full-text database, ScienceDirect full-text database, and the CNKI full-text database. The different effects and limitations of PRP were extracted.


A total of 108 articles were obtained, including 18 articles researching PRP in cells, 10 articles on animal research using PRP, 16 articles on the clinical study of PRP, 24 articles involving signs of skin aging, and four articles on the limitations of PRP. The remaining articles were related to the preparation of PRP, the introduction of PRP, and other aspects.


Based on in vitro and in vivo research, PRP may play a role in promoting tissue regeneration, oxidative stress and revascularization, which form the theoretical basis for the use of PRP in the clinical treatment of facial rejuvenation.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors


PRP Facial rejuvenation Skin aging Wrinkles 



This study was supported by the National Natural Science Foundation of China (No. 81171812, No. 81671924, and No. 81272105), the National Key Research and Development Plan of China (No. 2017YFC1103301), the National Basic Science and Development Program (No. 2012CB518105), Health and Medical Treatment Collaborative Innovation Major Special Projects of Guangzhou (No. 201508020253), the Science and Technology Program of Guangzhou (201508020115), and Science and Technology Project of Guangdong province (No. 2014B020212010, No. 508113150092, No. 2015A010101313, and No. 2017A050506011).

Compliance with Ethical Standards

Conflict of interest

The authors declared that they have no conflicts of interest in this work. We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2018

Authors and Affiliations

  1. 1.The Graduate School of Southern Medical UniversityGuangzhouChina
  2. 2.Center of Wound TreatmentGuangzhou General Hospital of Guangzhou Military CommandGuangzhouChina

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