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Aesthetic Plastic Surgery

, Volume 43, Issue 1, pp 253–266 | Cite as

Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons

  • Gordon H. SasakiEmail author
Original Article Special Topics
  • 310 Downloads

Abstract

Plastic surgeons are frequently asked to manage male- and female-pattern hair loss in their practice. This article discusses the epidemiology, pathophysiology, and current management of androgenetic alopecia and emphasizes more recent knowledge of stem cell niches in hair follicles that drive hair cycling, alopecia, and its treatment. The many treatment programs available for hair loss include newer strategies that involve the usage of growth factors, platelet-rich plasma, and fat to stimulate follicle growth. Future research may clarify novel biomolecular mechanisms that target specific cells that promote hair regeneration.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Keywords

Hair follicles Hair cycle Androgenetic alopecia Stem cell niches Treatment strategies 

Notes

Acknowledgements

The author wishes to thank Evelyn Avanessian, RN, Brigette Ibarra, LVN, for technical assistance in PRP isolation and cell counting; Sharon Cuellar, CST, for surgical assistance; Melissa Avitea, MA, for her IRB assistance; and Margaret Gaston, BS, for creating the artwork and providing the statistical and photographic assistance.

Compliance with Ethical Standards

Conflict of interest

The author is an unpaid consultant to Harvest Technologies Corp and MicroAire Surgical Instrument and declares no conflicts of interest with respect to the authorship and publication of this article. The author has neither financial nor investigational interests with Cytori Therapeutics, Inc. The author received no financial or equipment support from any of the device companies in this study. No financial support was provided for the writing of the article.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2018

Authors and Affiliations

  1. 1.Loma Linda Medical UniversityLoma LindaUSA
  2. 2.Private Practice: # 319PasadenaUSA

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